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Merck
CN

P5624

PD-118057

≥98% (HPLC), solid

Synonym(s):

2-[[4-[2-(3,4-Dichlorophenyl)ethyl]phenyl]amino]benzoic acid

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About This Item

Empirical Formula (Hill Notation):
C21H17Cl2NO2
CAS Number:
313674-97-4
Molecular Weight:
386.27
NACRES:
NA.77
PubChem Substance ID:
24724580
UNSPSC Code:
12352200
MDL number:
MFCD08705328

Key Documents

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Product Name

PD-118057, ≥98% (HPLC), solid

InChI

1S/C21H17Cl2NO2/c22-18-12-9-15(13-19(18)23)6-5-14-7-10-16(11-8-14)24-20-4-2-1-3-17(20)21(25)26/h1-4,7-13,24H,5-6H2,(H,25,26)

SMILES string

OC(=O)c1ccccc1Nc2ccc(CCc3ccc(Cl)c(Cl)c3)cc2

InChI key

ZCQOSCDABPVAFB-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

solid

color

light yellow

solubility

DMSO: 9 mg/mL

storage temp.

−20°C

Quality Level

100

Biochem/physiol Actions

Activator of ether-a-go-go-related (hERG) potassium channel. Used in the treatment of congestive heart failure.
PD-118057 is an activator of ether-a-go-go-related (hERG) potassium channel. PD-118057 is a second identified hERG channel activator, a representative in the series of structural analogs; PD-118057 at 10 μM leads to a 111% current increase in rabbit ventricular wedge (in comparison RPR260243 leads to only a 15% increase at the same concentration);PD-118057, unlike RPR260243, does not have a major effect on gating or kinetic properties of this channel. PD-118057prevents and reverses QT interval prolongation; Compounds such as PD-118057 may offer new approach in the treatment of delayed repolarization conditions, which occur in inherited or acquired long QT syndrome and congestive heart failure

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Aquatic Chronic 4 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000456490
0000456490
036K4606V
036K46062
036K46061

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Articles

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