Skip to Content
Merck
CN
All Photos(4)

Documents

P5585

Sigma-Aldrich

Palmitic acid

BioXtra, ≥99%

Sign Into View Organizational & Contract Pricing
All Photos(4)
Synonym(s):
1-Pentadecanecarboxylic acid, C16:0, Cetylic acid, Hexadecanoic acid, NSC 5030, PamOH
Linear Formula:
CH3(CH2)14COOH
CAS Number:
57-10-3
Molecular Weight:
256.42
Beilstein:
607489
EC Number:
200-312-9
MDL number:
MFCD00002747
UNSPSC Code:
12352106
PubChem Substance ID:
24898674
NACRES:
NA.25

biological source

plant (vegetable)

Quality Level

200

vapor pressure

10 mmHg ( 210 °C)

product line

BioXtra

Assay

≥99%

form

powder

technique(s)

cell culture | mammalian: suitable

impurities

≤0.0005% Phosphorus (P)
≤0.1% Insoluble matter

ign. residue

≤0.1%

bp

271.5 °C/100 mmHg (lit.)

mp

61-62.5 °C (lit.)

solubility

chloroform: 0.5 M, clear, colorless

density

0.852 g/mL at 25 °C (lit.)

anion traces

chloride (Cl-): ≤0.05%
sulfate (SO42-): ≤0.05%

cation traces

Al: ≤0.005%
Ca: ≤0.0005%
Cu: ≤0.0005%
Fe: ≤0.0005%
K: ≤0.005%
Mg: ≤0.0005%
NH4+: ≤0.05%
Na: ≤0.05%
Pb: ≤0.001%
Zn: ≤0.0005%

functional group

carboxylic acid

lipid type

saturated FAs

shipped in

ambient

storage temp.

room temp

SMILES string

CCCCCCCCCCCCCCCC(O)=O

InChI

1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)

InChI key

IPCSVZSSVZVIGE-UHFFFAOYSA-N

Gene Information

human ... FABP2(2169) , FABP3(2170) , FABP4(2167) , FABP5(2171)

Looking for similar products? Visit Product Comparison Guide

Related Categories

Application

Palmitic acid has been used:
  • as a medium supplement in chorionic villous tissue culture form placenta
  • as a component of hormone pellet for implantation in mice ovary
  • for inducing expression of immunity-related GTPase M (IRGM) in human monocytic cell line, THP-1

Biochem/physiol Actions

Palmitic acid (PA) is a component of membrane phospholipids (PL) and adipose triacylglycerols (TAG). Elevated levels of palmitic acid contributes to the pathophysiology of atherosclerosis, type 2 diabetes mellitus, neurodegenerative diseases, obesity and cancer. PA promotes apoptosis in the endothelial cell by modulating the p38 mitogen-activated protein kinase (MAPK) pathway and favors expression of TNF-α and reactive oxygen species accumulation. PA promotes interleukin 8 (IL-8) synthesis in hepatocytes contributing to hepatic inflammation. PA by interacting with toll-like receptor 4 (TLR4) induces inflammatory injury in cardiomyoctes.
Palmitic acid is a straight-chain 16-carbon fatty acid. Diets rich in palmitic acid, along with lauric and myristic acids, are associated with increased serum levels of low-density lipoprotein cholesterol. Palmitic acid is the first fatty acid produced by lipogenesis. It is a negative regulator of acetyl-CoA carboxylase (ACC) and is implicated in fatty acid-induced insulin resistance.

WGK

nwg

Flash Point(F)

235.4 °F

Flash Point(C)

113 °C

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Biological and nutritional properties of palm oil and palmitic acid: effects on health
Mancini A, et al.
Molecules (Basel), 20(9), 17339-17361 (2015)
Lipidomic Analysis of alpha Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment
Fanning S, et al.
Molecular Cell (2018)
Palmitic acid induced vascular endothelial cell apoptosis contributes to the high severity of coronary artery disease in the Uygur population
Jiang H, et al.
Biomedical Research, 28(2), 17339-17361 (2017)
Palmitic acid: Physiological role, metabolism and nutritional implications
Carta G, et al.
Frontiers in Physiology, 8, 902-902 (2017)
Palmitic acid induces production of proinflammatory cytokine interleukin-8 from hepatocytes
Joshi-Barve S, et al.
Hepatology, 46(3), 823-830 (2007)
View All Related Papers

Articles

Lipid-induced Insulin Resistance

Lipid Induced Insulin Resistance

Fatty Acid Synthesis in Cancer Cells

Fatty acid synthesis supports cancer cell proliferation, essential for membrane generation, protein modification, and bioenergetics.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service