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Merck
CN

P5155

D-Pantothenic acid hemicalcium salt

BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture

Synonym(s):

(R)-(+)-N-(2,4-Dihydroxy-3,3-dimethyl-1-oxobutyl)-β-alanine hemicalcium salt, Calcium D-pantothenate, Vitamin B5

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About This Item

Linear Formula:
HOCH2C(CH3)2CH(OH)CONHCH2CH2CO2 ·1/2Ca
CAS Number:
137-08-6
Molecular Weight:
238.27
NACRES:
NA.75
PubChem Substance ID:
24898601
eCl@ss:
34058012
UNSPSC Code:
12352205
EC Number:
205-278-9
MDL number:
MFCD00002766
Beilstein/REAXYS Number:
3769272

Key Documents

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Product Name

D-Pantothenic acid hemicalcium salt, BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture

InChI key

FAPWYRCQGJNNSJ-UBKPKTQASA-L

InChI

1S/2C9H17NO5.Ca/c2*1-9(2,5-11)7(14)8(15)10-4-3-6(12)13;/h2*7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13);/q;;+2/p-2/t2*7-;/m00./s1

SMILES string

CC(C)(CO)[C@@H](O)C(=O)NCCC(=O)O[Ca]OC(=O)CCNC(=O)[C@H](O)C(C)(C)CO

biological source

synthetic (organic)

product line

BioReagent

assay

≥98% (TLC)

form

powder

mol wt

Mw 238.27 g/mol

technique(s)

cell culture | insect: suitable
cell culture | mammalian: suitable
cell culture | plant: suitable

color

white to off-white

pH

7.0-8 (25 °C, 50 g/L)

solubility

water: soluble 50 mg/mL, clear, colorless

storage temp.

2-8°C

Quality Level

200

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Application

D-Pantothenic acid hemicalcium salt has been used:
  • as a component of FMX-turbodoma- derived media
  • as a supplement in DMEM (Dulbecco′s modified eagle media)/F-12 used for cell proliferation
  • as a supplement in preadipocyte media

Precursor in the biosynthesis of coenzyme A.

Biochem/physiol Actions

Along with coenzyme A (CoA, D-pantothenic acid is a precursor for acyl carrier protein. These are essential cofactors involved in fat, protein and carbohydrate metabolism. It also participates in the formation of acetylcholine neurotransmitter. D-pantothenic acid is considered as a source of nutrition and possesses immune function by mediating antibody formation. The production of cortisone is supported by D-pantothenic acid. It is essential for adrenal gland activity.

General description

Due to the unstable, hygroscopic nature of the free acid, the calcium salt is employed.
Plants and microorganisms, such as Escherichia coli are the major sources of D-pantothenic acid. It is water soluble and quite stable to heating.

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
WXBF7809V
WXBF6477V
WXBF5923V
WXBF5465V
WXBF4789V

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Stopping the Clock, 184-184 (2003)
3T3-L1 cells and perivascular adipocytes are not equivalent in amine transporter expression
Ismail A, et al.
Febs Letters, 591(1), 137-144 (2017)
LipiD-QuanT: a novel method to quantify lipid accumulation in live cells.
Varinli H, et al.
Journal of Lipid Research, 56(11), 2206-2216 (2015)
The role of vitamins and amino acids on hybridoma growth and monoclonal antibody production
Ducommun P, et al.
Cytotechnology, 37(2), 65-73 (2001)
Organisation of the pantothenate (vitamin B5) biosynthesis pathway in higher plants
Ottenhof HH, et al.
The Plant Journal, 37(1), 61-72 (2004)
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