P4997
Anti-Potassium Channel KCa3.1 (Intermediate-conductance Ca2+-activated Potassium Channel 4) antibody produced in rabbit
affinity isolated antibody, lyophilized powder
Synonym(s):
Anti-IKCa1, Anti-KCNN4, Anti-SK4
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About This Item
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
human, rat, mouse (predicted)
technique(s)
western blot: 1:200
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... KCNN4(3783)
mouse ... Kcnn4(16534)
rat ... Kcnn4(65206)
Immunogen
synthetic peptide corresponding to amino acid residues 350-363 of rat KCa3.1. The sequence has 100% homology with human, mouse, and pig.
Application
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)
Western Blotting (1 paper)
Immunofluorescence (1 paper)
Western Blotting (1 paper)
Physical form
Lyophilized powder from phosphate buffered saline containing 1% bovine serum albumin and 0.05% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
含少量动物源组分生物产品
常规特殊物品
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Valentina Back et al.
Journal of thrombosis and haemostasis : JTH, 20(11), 2587-2600 (2022-07-23)
Within the vasculature platelets and endothelial cells play crucial roles in hemostasis and thrombosis. Platelets, like endothelial cells, possess intermediate conductance Ca2+ -activated K+ (IKCa ) channels and generate nitric oxide (NO). Although NO limits platelet aggregation, the role of
Yi-Je Chen et al.
PloS one, 8(11), e81006-e81006 (2013-12-07)
Allograft vasculopathy (AV) remains one of the major challenges to the long-term functioning of solid organ transplants. Although its exact pathogenesis remains unclear, AV is characterized by both fibromuscular proliferation and infiltration of CD4(+) memory T cells. We here tested
Eva M Grössinger et al.
Journal of immunology (Baltimore, Md. : 1950), 200(2), 749-757 (2017-12-17)
In inflammatory arthritis, the dysregulation of osteoclast activity by proinflammatory cytokines, including TNF, interferes with bone remodeling during inflammation through Ca2+-dependent mechanisms causing pathological bone loss. Ca2+-dependent CREB/c-fos activation via Ca2+-calmodulin kinase IV (CaMKIV) induces transcriptional regulation of osteoclast-specific genes
Lee-Way Jin et al.
Annals of clinical and translational neurology, 6(4), 723-738 (2019-04-26)
Microglia play a pivotal role in the initiation and progression of Alzheimer's disease (AD). We here tested the therapeutic hypothesis that the Ca2+-activated potassium channel KCa3.1 constitutes a potential target for treating AD by reducing neuroinflammation. To determine if KCa3.1
Katy M Roach et al.
PloS one, 8(12), e85244-e85244 (2014-01-07)
Idiopathic pulmonary fibrosis (IPF) is a common, progressive and invariably lethal interstitial lung disease with no effective therapy. We hypothesised that K(Ca)3.1 K(+) channel-dependent cell processes contribute to IPF pathophysiology. K(Ca)3.1 expression in primary human lung myofibroblasts was examined using
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