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P4663

Poly-L-arginine hydrochloride

Name: Poly-<SC>L</SC>-arginine hydrochloride
Brand: SIGMA

mol wt 5,000-15,000

Synonym(s):

L-Arginine homopolymer hydrochloride

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About This Item

CAS Number:

26982-20-7

MDL number:

MFCD00166393

UNSPSC Code:

12352209

eCl@ss:

32160406

PubChem Substance ID:

24898490

NACRES:

NA.26

form

powder

Quality Level

200

mol wt

5,000-15,000

color

white to off-white

application(s)

cell analysis
detection

storage temp.

−20°C

SMILES string

Cl.NC(CCCNC(N)=N)C(O)=O

InChI

1S/C18H38N12O4.ClH/c19-10(4-1-7-26-16(20)21)13(31)29-11(5-2-8-27-17(22)23)14(32)30-12(15(33)34)6-3-9-28-18(24)25;/h10-12H,1-9,19H2,(H,29,31)(H,30,32)(H,33,34)(H4,20,21,26)(H4,22,23,27)(H4,24,25,28);1H/t10-,11-,12-;/m0./s1

InChI key

PQEISBBDIRAKGR-LFELFHSZSA-N

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Related Categories

Amino Acids

Application

Interfacial Electrostatics of Poly(vinylamine hydrochloride), Poly(diallyldimethylammonium chloride), Poly-L-lysine, and Poly-L-arginine Interacting with Lipid Bilayers.: This research investigates the interactions between poly-L-arginine hydrochloride and lipid bilayers, providing insights into its potential applications in drug delivery systems (McGeachy et al., 2018). (McGeachy et al., 2018).

Quality

Contains 3% or less ornithine residue.

Analysis Note

Molecular weight based on viscosity of precursor poly-L-ornithine.

Other Notes

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Improved nasal absorption of drugs using poly-L-arginine: effects of concentration and molecular weight of poly-L-arginine on the nasal absorption of fluorescein isothiocyanate-dextran in rats.

M Miyamoto et al.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 52(1), 21-30 (2001-07-05)

The effects of the concentration and molecular weight of poly-L-arginine (poly-L-Arg) on the in vivo nasal absorption of fluorescein isothiocyanate-labeled dextran (MW, 4 kDa, FD-4) in rats were studied. When poly-L-Arg with a range of different molecular weights (MW, 8.9

Tau peptides and tau mutant protein aggregation inhibition by cationic polyethyleneimine and polyarginine.

Keerthi Nadimidla et al.

Biopolymers, 107(9) (2017-05-01)

Tau protein plays a major role in Alzheimer's disease. The tau protein loses its functionality by self-aggregation due to the two six-amino acid sequences VQIVYK and VQIINK of the protein. Hence it is imperative to find therapeutics that could inhibit

Analysis of transient and reversible effects of poly-L-arginine on the in vivo nasal absorption of FITC-dextran in rats.

Ohtake K, Natsume H, Ueda H, et al.

J. Controlled Release, 82, 263-275 (2002)

Heparin and Arginine Based Plasmin Nanoformulation for Ischemic Stroke Therapy.

Ramsha Aamir et al.

International journal of molecular sciences, 22(21) (2021-11-14)

Ischemic stroke is the most common type of stroke and thrombolytic therapy is the only approved treatment. However, current thrombolytic therapy with tissue plasminogen activator (tPA) is often hampered by the increased risk of hemorrhage. Plasmin, a direct fibrinolytic, has

An epigenetic GPI anchor defect impairs TLR4 signaling in the B cell transdifferentiation model for primary human monocytes BLaER1.

Julia Wegner et al.

Scientific reports, 11(1), 14983-14983 (2021-07-24)

Antigen-presenting myeloid cells like monocytes detect invading pathogens via pattern recognition receptors (PRRs) and initiate adaptive and innate immune responses. As analysis of PRR signaling in primary human monocytes is hampered by their restricted expandability, human monocyte models like THP-1 cells

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Poly(Amino Acid) Block Copolymers for Drug Delivery and other Biomedical Applications

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