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P4620

Sigma-Aldrich

PD 146176

≥98% (HPLC), solid

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Synonym(s):
6,11-Dihydro[1]benzothiopyrano[4,3-b]indole
Empirical Formula (Hill Notation):
C15H11NS
CAS Number:
4079-26-9
Molecular Weight:
237.32
MDL number:
MFCD05664738
UNSPSC Code:
12352200
PubChem Substance ID:
24724579
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

solid

color

white to beige

solubility

DMSO: soluble >10 mg/mL
H2O: insoluble

SMILES string

C1Sc2ccccc2-c3[nH]c4ccccc4c13

InChI

1S/C15H11NS/c1-3-7-13-10(5-1)12-9-17-14-8-4-2-6-11(14)15(12)16-13/h1-8,16H,9H2

InChI key

ZGOOPZVQMLHPFM-UHFFFAOYSA-N

Gene Information

human ... ALOX15(246)
mouse ... ALOX15(11687)
rat ... ALOX15(81639)

Application

PD 146176 has been used to study its influence on ex vivo leukotriene B4 (LTB4) and lipoxin A4 (LXA4) secretion in adipose tissue.

Biochem/physiol Actions

PD 146176 blocks neuroprotectin D1 (NPD1) and eicosanoid synthesis by inhibiting the 5-lipoxygenase-1 (15-LOX-1) enzyme.
15-Lipoxygenase inhibitor

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Retinal pigment epithelium and photoreceptor preconditioning protection requires docosanoid signaling
Knott EJ, et al.
Cellular and Molecular Neurobiology, 38(4), 901-917 (2018)
David M Tobin et al.
PloS one, 8(7), e67828-e67828 (2013-07-23)
While tuberculosis susceptibility has historically been ascribed to failed inflammation, it is now known that an excess of leukotriene A4 hydrolase (LTA4H), which catalyzes the final step in leukotriene B4 (LTB4) synthesis, produces a hyperinflammatory state and tuberculosis susceptibility. Here
Jiang Yang et al.
Scientific reports, 9(1), 13316-13316 (2019-09-19)
Ovarian cancer (OvCa), while accounting for only 3% of all women's cancer, is the fifth leading cause of cancer death among women. One of the most significant obstacles to successful OvCa treatment is chemoresistance. The current lack of understanding of
Chi-Yuan Lee et al.
Micromachines, 11(12) (2020-12-10)
The hydrogen production reaction of the proton exchange membrane (PEM) water electrolysis cell stack is the reverse reaction of the fuel cell, but the water electrolysis operation requires high pressure, and the high pressure decomposes hydrogen molecules, thus aging or
ALOX5AP overexpression in adipose tissue leads to LXA4 production and protection against diet-induced obesity and insulin resistance
Elias I, et al.
Diabetes, 65(8), 2139-2150 (2016)
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