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P4484

Sigma-Aldrich

Purvalanol A

≥98% (HPLC), powder

Synonym(s):

2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine, NG-60

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About This Item

Empirical Formula (Hill Notation):
C19H25ClN6O
CAS Number:
212844-53-6
Molecular Weight:
388.89
MDL number:
MFCD02179211
UNSPSC Code:
12352200
PubChem Substance ID:
24898543
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

solubility

methylene chloride: 50 mg/mL

shipped in

dry ice

storage temp.

−20°C

SMILES string

CC(C)[C@H](CO)Nc1nc(Nc2cccc(Cl)c2)c3ncn(C(C)C)c3n1

InChI

1S/C19H25ClN6O/c1-11(2)15(9-27)23-19-24-17(22-14-7-5-6-13(20)8-14)16-18(25-19)26(10-21-16)12(3)4/h5-8,10-12,15,27H,9H2,1-4H3,(H2,22,23,24,25)/t15-/m0/s1

InChI key

PMXCMJLOPOFPBT-HNNXBMFYSA-N

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Show Differences

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This Item
P5234540500164640
Purvalanol A ≥98% (HPLC), powder

P4484

Purvalanol A

Purvalanol B ≥97% (HPLC), solid

P5234

Purvalanol B

Purvalanol A A potent, cell-permeable, reversible, and selective inhibitor of cyclin-dependent kinases.

540500

Purvalanol A

Aminopurvalanol A A cell-permeable 2,6,9-trisubstituted purine analog that displays anti-mitotic as well as anti-tumor properties.

164640

Aminopurvalanol A

assay

≥98% (HPLC)

assay

≥97% (HPLC)

assay

≥97% (HPLC)

assay

≥98% (HPLC)

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

solubility

methylene chloride: 50 mg/mL

solubility

DMSO: soluble 37 mg/mL, H2O: insoluble

solubility

DMSO: 100 mg/mL

solubility

DMSO: 40 mg/mL

shipped in

dry ice

shipped in

dry ice

shipped in

ambient

shipped in

ambient

Biochem/physiol Actions

Purvalanol A is a potent, cell-permeable cyclin-dependent protein kinase (cdk) inhibitor.
Purvalanol A is found to inhibit ABCG2 (ATP-binding cassette G2) transporter in vitro.[1] It is also known to attenuate cellular Src kinase action and induce cell cycle arrest at the G2 to M phase transition.[2]

Features and Benefits

This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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    Certificates of Analysis (COA)

    Lot/Batch Number
    SLBW7285
    SLBJ4683V
    SLBF0810V
    SLBB8504V
    SLBB1919V

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