Skip to Content
Merck
CN
All Photos(1)

Key Documents

View All Documentation

Safety Information

P4371

Sigma-Aldrich

Anti-Potassium Channel KCNQ2 antibody produced in rabbit

affinity isolated antibody, lyophilized powder

Synonym(s):

Anti-KV7.2, Anti-Voltage-gated potassium channel QKT subfamily member 2

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

MDL number:
MFCD06411903
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

rat

technique(s)

western blot: 1:200 using KCNQ2 transfected HEK-293 cells

UniProt accession no.

O88943

storage temp.

−20°C

Gene Information

human ... KCNQ2(3785)
mouse ... Kcnq2(16536)
rat ... Kcnq2(170848)

General description

Potassium voltage-gated channel subfamily Q member 2 (KCNQ2) is one of the five isoforms of KCNQ channels. It is expressed in the central and peripheral nervous system.

Specificity

The antibody does not cross-react with KCNQ3 or other QKT proteins. There are at least 9 splice variants of rat KCNQ2. The antibody recognizes all splice variants except B and G.

Immunogen

peptide corresponding to amino acid residues 578-593 of rat KCNQ2. This epitope is identical in mouse and highly homologous in human (15/16 residues identical).

Biochem/physiol Actions

Potassium voltage-gated channel subfamily Q member 2 (KCNQ2) acts as a mediator of sub-threshold activated muscarinic-regulated K+ current (M-current). It modulates neuronal excitability. Mutations in the gene encoding this protein have been associated with benign neonatal familial convulsions.

Physical form

Lyophilized at ~0.7 mg/ml from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.025% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Not finding the right product?  

Try our Product Selector Tool.

Regulatory Information

新产品

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
104K0840
104K0839
094K0926
014K1029

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Activation of peripheral KCNQ channels relieves gout pain.
Zheng Y
Pain (2015)
Involvement of KCNQ2 subunits in [3H]dopamine release triggered by depolarization and pre-synaptic muscarinic receptor activation from rat striatal synaptosomes
Maria M
Journal of Neurochemistry (2007)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service