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biological source
synthetic (organic)
Quality Level
Assay
≥98% (TLC)
form
lyophilized powder
solubility
water: 4.80-5.20 mg/mL, clear to hazy, colorless to faintly yellow
storage temp.
−20°C
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Application
Polyinosinic acid (Poly(I)) is a homopolymer of inosine that may be used with polycytidylic acid (poly(C)) to form the double-stranded homopolymer (Poly(I) • Poly(C)). TLR3 recognizes double-stranded RNA and is a major effector of the immune response against viral pathogens. (Poly(I) • Poly(C)) is a used as a model RNA to study cell signaling at the level of TLR3. Poly(IC) is a TRIF-dependent toll-like receptor-3 (TLR3) ligand.
Preparation Note
Prepared from IDP using polynucleotide phosphorylase.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Gennady Dvoryanchikov et al.
Nature communications, 8(1), 760-760 (2017-10-04)
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RNA binding ability and cellular distribution are important for nonstructural protein 1 (NS1) of influenza A virus to act as a viral regulatory factor to control virus life cycle. In this study, we identified that the N-terminal residues 19-21 of
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Packiriswamy N, Parvataneni S, Parameswaran N.
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Caiqi Ma et al.
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Gastric cancer is one of the most malignant tumor types, and its metastasis is a notable cause of mortality. Among the methods of tumor metastasis, lymphatic metastasis is the predominant one in gastric cancer. A previous study reported that the
Hui-Ching Chuang et al.
Oral oncology, 48(3), 226-232 (2011-11-11)
Chronic inflammation associated with some infectious agents can lead to cancer. The Toll-like receptor (TLR) family is one of the largest and best-studied families of pathogen-associated molecular patterns. TLR3 recognizes double-stranded RNA and is a major effector of the immune
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