P3338
Prostate Specific Antigen from human semen
buffered aqueous solution
Synonym(s):
Cancer-associated PSA, PSA
Product Name
Prostate Specific Antigen from human semen, buffered aqueous solution
biological source
human semen
assay
≥95% (SDS-GE)
form
buffered aqueous solution
UniProt accession no.
storage temp.
2-8°C
Quality Level
Gene Information
human ... KLK3(354)
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Analysis Note
Highly purified
Application
Prostate Specific Antigen from human semen has been used:
- in microarray sandwich assay
- in the preparation of sandwich immunosensor
- as a target protein to test composite organic−inorganic nanoparticle (COIN) and Alexa conjugates in a plate-binding assay
Biochem/physiol Actions
Glycoprotein of the glandular kallikrein family
Prostate Specific Antigen (PSA), a glycoprotein of the glandular kallikrein family, is a serine protease with chymotrypsin-like enzymatic activity. Circulating PSA exists in free and protease inhibitor-bound forms. Studying the ratios of free to inhibitor-bound forms may prove valuable in the diagnosis of prostate cancer.
Prostate-specific antigen (PSA) is an androgen-regulated serine protease specifically produced by prostatic tissue and is secreted into the lumen. PSA in semen cleaves semenogelins present in the seminal coagulum. Total PSA levels are increased in serum of prostate cancer (PCa) patients. PSA functions as a potential biomarker for PCa. Serum protease inhibitors such as α1-antichymotrypsin (α1-ACT), α2-macroglobulin (α2-M), and other acute-phase proteins form irreversible complexes with circulating PSA and hinder proteolytic activity of PSA.
General description
Prostate specific antigen (PSA) is a 28.43 kDa single-chain glycoprotein containing 237 amino acids, encoded by the kallikrein gene mapped to human chromosome 19. It is specifically expressed by human prostate tissue and is one of the highly abundant proteolytic enzyme expressed in the seminal fluid.
Packaging
Package size based on protein content
Physical form
Solution in phosphate buffered saline, contains 0.05-0.1% sodium azide with 50% glycerol
Storage Class
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Microarray-based multiplexed scanometric immunoassay for protein cancer markers using gold nanoparticle probes.
Kim D
Analytical Chemistry, 81(21), 183-187 (2009)
Barry Lutz et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 56(4), 371-379 (2007-12-12)
Surface-enhanced Raman scattering (SERS) nanoparticles are emerging as a new approach for optical detection of biomolecules. In a model assay in formalin-fixed paraffin-embedded (FFPE) prostate tissue sections, we detect prostate-specific antigen (PSA) using antibody (Ab) conjugated to composite organic-inorganic nanoparticles
A M Zhou et al.
Clinical chemistry, 39(12), 2483-2491 (1993-12-01)
Prostate-specific antigen (PSA) in serum is primarily complexed with alpha 1-antichymotrypsin (alpha 1-ACT). However, 12-15% of prostate cancer (PCa) patients present with the predominant form being uncomplexed (free) PSA (Lilja et al., Clin Chem 1991;37:1618-24). We report that commercial immunoassays
Usefulness of total PSA value in prostate diseases diagnosis
Prcic A, et al.
Acta Informatica Medica, 24(3), 156-156 (2016)
Agnieszka Stolarczyk et al.
Sensors (Basel, Switzerland), 22(4) (2022-02-27)
The detection of chemicals is a fundamental issue of modern civilisation, however existing methods do not always achieve the desired sensitivity. Preconcentrators, which are devices that allow increasing the concentration of the intended analyte via e.g., adsorption/desorption, are one of
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