P3134
Phosphodiesterase I from Crotalus adamanteus venom
Type VI, crude dried venom
Synonym(s):
5′-Exonuclease, Oligonucleate 5′-nucleotidohydrolase
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About This Item
CAS Number:
UNSPSC Code:
12352204
NACRES:
NA.54
EC Number:
232-806-5
MDL number:
General description
Research area: Cell signaling. PhosphodiesteraseI (PDEI) exists in three isoforms PDE1A, PDE1B, and PDE1C(2) are localized to the central nervous system, cardiovascular, and other organs.
Application
Phosphodiesterase I from Crotalus adamanteus venom has been used:
- for cleaving the 3′-5′ internucleotide bonds in the linear chains of the RNA oligomers
- as a model for the hydrolysis of prodrugs in phosphodiesterase assay
- as a component in the nucleotide cleavage buffer
Biochem/physiol Actions
Phosphodiesterase I breaks phosphodiester bonds and catalyzes the hydrolysis of various nucleotide polyphosphates. Phosphodiesterase I is released from eucaryotic plasma membranes by phosphatidylinositol-specific phospholipase C. PhosphodiesteraseI (PDEI) can hydrolyze 3′,5′-cyclic adenosine monophosphate (cAMP) and3′,5′-cyclic guanosine monophosphate (cGMP). It binds to Ca2+/calmodulin(CaM) that lead to the stimulation of its catalytic activity.PDEIacts as a biotherapeutic for the treatment of cancer, heart diseases,pulmonary, metabolic, neurocognitive, renal, endocrine abnormalities, andneurological disorders.
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signalword
Danger
hcodes
pcodes
Hazard Classifications
Resp. Sens. 1
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
低风险生物材料
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Ester prodrugs of acyclic nucleoside thiophosphonates compared to phosphonates: synthesis, antiviral activity and decomposition study
Roux L, et al.
European Journal of Medicinal Chemistry, 63, 869-881 (2013)
Anatoly I Dragan et al.
Nucleic acids research, 32(17), 5192-5197 (2004-10-02)
The interaction of proteins with DNA results, in some cases, in DNA bending, and this might have functional importance. However, when the protein-induced bending of DNA is small, its measurement presents a problem. It is shown that the fluorescence resonance
Ozone-Induced DNA Damage: A Pandora?s Box of Oxidatively Modified DNA Bases
Richard W J, et al.
Chemical Research in Toxicology (2021)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| P3134-100MG | 04061832758800 |