P3028
Perhexiline maleate salt
Synonym(s):
2-(2,2-Dicyclohexylethyl)piperidine
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About This Item
Empirical Formula (Hill Notation):
C19H35N · C4H4O4
CAS Number:
Molecular Weight:
393.56
UNSPSC Code:
41116107
PubChem Substance ID:
EC Number:
229-775-5
MDL number:
InChI key
JDZOTSLZMQDFLG-BTJKTKAUSA-N
InChI
1S/C19H35N.C4H4O4/c1-3-9-16(10-4-1)19(17-11-5-2-6-12-17)15-18-13-7-8-14-20-18;5-3(6)1-2-4(7)8/h16-20H,1-15H2;1-2H,(H,5,6)(H,7,8)/b;2-1-
SMILES string
OC(=O)\C=C/C(O)=O.C1CCC(CC1)C(CC2CCCCN2)C3CCCCC3
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
forensics and toxicology
veterinary
Biochem/physiol Actions
Anti-anginal metabolic modulator; carnitine palmitoyltransferase inhibitor
Coronary vasodilator
Perhexiline maleate is an anti-anginal metabolic modulator. It inhibits the mitochondrial enzyme carnitine palmitoyltransferase CPT-1 and to a lesser extent CPT-2. This causes a shift in myocardial substrate utilisation from long chain fatty acids to carbohydrates, resulting in increased glucose and lactate utilization and increased ATP production for the same O2 consumption as before and consequently increases myocardial efficiency. Perhexiline maleate was also recently found to inhibit the activity of mTORC1.
Storage Class
13 - Non Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Stephanie A Schnell et al.
Blood, 125(18), 2806-2814 (2015-03-19)
Oncogenic activation of NOTCH1 signaling plays a central role in the pathogenesis of T-cell acute lymphoblastic leukemia, with mutations on this signaling pathway affecting more than 60% of patients at diagnosis. However, the transcriptional regulatory circuitries driving T-cell transformation downstream
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