P2906
Poly(ethylene glycol)
Hybri-Max™, mol wt 3,000-3,700, waxy solid, BioReagent, suitable for hybridoma
Synonym(s):
Polyethylene glycol, PEG
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About This Item
Linear Formula:
H(OCH2CH2)nOH
CAS Number:
NACRES:
NA.75
PubChem Substance ID:
UNSPSC Code:
12161902
MDL number:
InChI
1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2
SMILES string
C(CO)O
InChI key
LYCAIKOWRPUZTN-UHFFFAOYSA-N
biological source
synthetic (organic)
grade
Hybri-Max™
sterility
autoclaved
product line
BioReagent
form
waxy solid
mol wt
3,000-3,700
technique(s)
cell culture | hybridoma: suitable
impurities
endotoxin, tested
Quality Level
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Legal Information
Hybri-Max is a trademark of Sigma-Aldrich Co. LLC
Application
Poly(ethylene glycol) has been used in the production of monoclonal antibodies.
Recommended for cell fusion.
Recommended for cell fusion.
General description
Poly(ethylene glycol) (PEG) is a non-ionic hydrophilic polymer and is available in different molecular weights. It either exists in the form of a linear or branched structure. It aids in the purification and crystal growth of proteins and nucleic acids. PEG along with dextran is used to achieve an aqueous polymer two-phase system, which is essential for the purification of biological materials. It permits cell fusion through its interaction with the cell membrane.
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
281.5 °F - closed cup
flash_point_c
138.6 °C - closed cup
ppe
Eyeshields, Gloves, type N95 (US)
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Harris JM
Poly(Ethylene Glycol) Chemistry: Biotechnical and Biomedical Applications (2013)
Extensive nuclear localization of alpha-synuclein in normal rat brain neurons revealed by a novel monoclonal antibody
Yu S, et al.
Neuroscience journal, 145(2), 539-555 (2007)
Agathe Dubuisson et al.
Cell death & disease, 10(2), 101-101 (2019-02-06)
Development of therapeutic antibodies in oncology has attracted much interest in the past decades. More than 30 of them have been approved and are being used to treat patients suffering from cancer. Despite encouraging results, and albeit most clinical trials
I L Konorova et al.
Patologicheskaia fiziologiia i eksperimental'naia terapiia, (4)(4), 7-9 (1991-07-01)
The search for antiaggregatory compounds is undertaken, as a rule, under in vitro conditions which do not reflect the dynamics of the real process. The present work deals with study of the peculiarities of the development of the collagen induced
Idalis Villanueva et al.
Acta biomaterialia, 5(8), 2832-2846 (2009-06-11)
The pericellular matrix (PCM) surrounding chondrocytes is thought to play an important role in transmitting biochemical and biomechanical signals to the cells, which regulates many cellular functions including tissue homeostasis. To better understand chondrocytes interactions with their PCM, three-dimensional poly(ethylene
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