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P2658

Sigma-Aldrich

Poly-L-lysine hydrochloride

suitable for cell culture, Mol wt 15,000-30,000

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Synonym(s):
L-Lysine hydrochloride homopolymer
CAS Number:
26124-78-7
MDL number:
MFCD00081870
UNSPSC Code:
12352209
eCl@ss:
32160406
NACRES:
NA.26

form

powder or solid

Quality Level

200

mol wt

15,000-30,000

technique(s)

cell culture | mammalian: suitable

color

white to light yellow

application(s)

cell analysis

storage temp.

−20°C

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Application

Poly-L-lysine hydrochloride has been used to coat glass slides and coverslips to facilitate cell attachment.
Poly-lysine with mol. wt. >70,000 is useful in promoting cell adhesion to solid substrates.

Biochem/physiol Actions

L-Lysine is believed to prevent osteoporosis of bones, which is a characteristics of vascular calcification. Glutaric aciduria type I and pyridoxine-dependent epilepsy occurs due to lack of L-lysine catabolic pathway. Lysine participates in the regulation of NO (nitric oxide) synthesis. It possesses antiviral activity, therefore it is used in the treatment of Herpes simplex. L-Lysine is associated with a number of biochemical reactions such as acetylation, O-linked glycosylation, ubiquitination and protein methylation. Poly-L-lysine is considered as a biocompatible polymer and serves for the purpose of drug delivery across cell membrane. It is useful as one of the nanosized contrast agents in MRI (magnetic resonance imaging).

Analysis Note

Molecular weight based on viscosity.

Other Notes

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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The role of signaling pathways on proliferation and self-renewal of cultured bovine primitive germ cells
Sahare Mahesh
Reproductive medicine and biology, 14(1) (2015)
Multi-technique characterization of poly-L-lysine dendrigrafts-Cu(II) complexes for biocatalysis.
Rossi JC
Macromolecular Bioscience, 15(2), 275-290 (2015)
Archishman Ghosh et al.
Proceedings of the National Academy of Sciences of the United States of America, 116(39), 19474-19483 (2019-09-12)
Membraneless organelles, corresponding to the droplet phase upon liquid-liquid phase separation (LLPS) of protein or protein-RNA mixtures, mediate myriad cellular functions. Cells use a variety of biochemical signals such as expression level and posttranslational modification to regulate droplet formation and
Mahesh Sahare et al.
Reproduction, fertility, and development, 28(12), 2039-2050 (2015-07-17)
Spermatogonial stem cells (SSCs) are unipotent in nature, but mouse SSCs acquire pluripotency under the appropriate culture conditions. Although culture systems are available for rodent and human germ-cell lines, no proven culture system is yet available for livestock species. Here
Understanding cerebral L-lysine metabolism: the role of L-pipecolate metabolism in Gcdh-deficient mice as a model for glutaric aciduria type I.
Posset R
Journal of inherited metabolic disease, 38(2), 265-272 (2015)
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