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Merck
CN

P2607

PRE-084

σ1 opioid receptor agonist, solid

Synonym(s):

2-(4-morpholinethyl)-1-phenylcyclohexanecarboxylate hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C19H27NO3 · HCl
Molecular Weight:
353.88
UNSPSC Code:
12352200
PubChem Substance ID:
24278627
NACRES:
NA.77
MDL number:
MFCD00673883
Form:
solid
Quality level:
200

Key Documents

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Product Name

PRE-084, solid

form

solid

SMILES string

Cl.O=C(OCCN1CCOCC1)C2(CCCCC2)c3ccccc3

InChI

1S/C19H27NO3.ClH/c21-18(23-16-13-20-11-14-22-15-12-20)19(9-5-2-6-10-19)17-7-3-1-4-8-17;/h1,3-4,7-8H,2,5-6,9-16H2;1H

InChI key

QUJWFJNHTBKCLU-UHFFFAOYSA-N

description

Drug Control: Új pszichoaktív anyag / New psychoactive substance (Hungary), 78/2022. (XII. 28.) BM rendelet.

drug control

Új pszichoaktív anyag / New psychoactive substance (Hungary), 78/2022. (XII. 28.) BM rendelet

solubility

H2O: ≤24 mg/mL

Quality Level

200

Gene Information

human ... OPRS1(10280)
rat ... Oprs1(29336), Slc6a3(24898)

Related Categories

Biochem/physiol Actions

PRE-084 is a potent and highly selective σ1 opioid receptor agonist. It offers neuroprotection upon embolic stroke.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000275530
0000240438
0000275530
0000240438
0000203510

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Yuriko Kimura et al.
PloS one, 8(10), e75760-e75760 (2013-10-12)
Sigma-1 receptor (Sig-1R) is an integral membrane protein predominantly expressed in the endoplasmic reticulum. Sig-1R demonstrates a high affinity to various synthetic compounds including well-known psychotherapeutic drugs in the central nervous system (CNS). For that, it is considered as an
Li-Li Ji et al.
Molecular medicine reports, 16(4), 4987-4993 (2017-08-10)
Accumulating evidence has demonstrated that the σ-1 receptor (σ‑1R) possesses neuroprotective effects and is a potential novel therapeutic target for certain psychiatric diseases, including post‑traumatic stress disorder (PTSD) accompanied with anxiety disorder. It has been reported that σ‑1R agonist treatment
T Maurice et al.
British journal of pharmacology, 127(2), 335-342 (1999-06-29)
1. Sigma (sigma) receptor ligands were previously reported to alleviate learning and memory impairments on several pharmacological and pathological rodent models of amnesia. Such effect was demonstrated as involving the sigma1 subtype of sigma receptor. 2. In this study, we
Judit Hodrea et al.
International journal of molecular sciences, 24(14) (2023-07-29)
Primary open-angle glaucoma remains a global issue, lacking a definitive treatment. Increased intraocular pressure (IOP) is considered the primary risk factor of the disease and it can be caused by fibrotic-like changes in the trabecular meshwork (TM) such as increased
Sigma-1 receptor ligand PRE-084 reduced infarct volume, neurological deficits, pro-inflammatory cytokines and enhanced anti-inflammatory cytokines after embolic stroke in rats
Allahtavakoli M and Jarrott B
Brain Research Bulletin, 85(3-4), 219-224 (2011)
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