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P2517

Sigma-Aldrich

L-α-Phosphatidylinositol ammonium salt solution from bovine liver

10 mg/mL in chloroform, ≥98% (TLC)

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Synonym(s):
1,2-Diacyl-sn-glycero-3-phospho-(1-D-myo-inositol), PI, PtdIns
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

200

Assay

≥98% (TLC)

concentration

10 mg/mL in chloroform

storage temp.

−20°C

Biochem/physiol Actions

Phosphatidylinositol is a phosphoglyceride, containing inositol as a cyclohexanol head group. The phosphatidylinositol signaling pathway is also called as double signaling pathway as it generates two secondary messengers. It is associated with a number of physiological processes in plants. This includes the development of pollen and vascular organs, root and root hair growth, hormone response and stress tolerance.
Phospholipid membrane component, precursor of inositol phosphates.

Features and Benefits

This compound is featured on the Phosphoinositide Kinases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Other Notes

Contains primarily stearic and arachidonic acids.

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Target Organs

Central nervous system, Liver,Kidney

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

危险化学品
易制毒化学品（2类）

Certificates of Analysis (COA)

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S J Heydrick et al.
The Journal of clinical investigation, 91(4), 1358-1366 (1993-04-01)
Activation of phosphatidylinositol-3-kinase (PI3K) is one of the earliest postreceptor events in the insulin signaling pathway. Incubation of soleus muscles from lean mice with 50 nM insulin caused a 3-10-fold increase in antiphosphotyrosine-immunoprecipitable PI3K (antiPTyr-PI3K) activity within 2 min in
Cell Biology, 471-471 (2007)
D Voelker et al.
Biophysical journal, 70(2), 818-830 (1996-02-01)
We have measured the distribution of the hexavalent ruthenium red cation (RuR) between water and phospholipid membranes, have shown the critical importance of membrane negative surface charge for RuR binding, and determined the association constant of RuR for different phospholipid
Sarah J Tilley et al.
Structure (London, England : 1993), 12(2), 317-326 (2004-02-14)
Phosphatidylinositol transfer protein alpha (PITPalpha) selectively transports and promotes exchange of phosphatidylinositol (PI) and phosphatidylcholine (PC) between lipid bilayers. In higher eukaryotes PITPalpha is required for cellular functions such as phospholipase C-mediated signaling, regulated exocytosis, and secretory vesicle formation. We
Functional Characterization of Arabidopsis Phosphatidylinositol Monophosphate 5-kinase 2 in Lateral Root Development, Gravitropism and Salt Tolerance, 2-2 (2014)
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Protocols

LC/MS Analysis of Phospholipids in Milk on Asc

(soybean), ≥97%; L-α-Phosphatidylethanolamine from egg yolk, Type III, ≥97% (TLC), lyophilized powder; L-α-Phosphatidylcholine, from egg yolk, Type XVI-E, ≥99% (TLC), lyophilized powder; Sphingomyelin, from chicken egg yolk, ≥95%

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