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P2516

Sigma-Aldrich

Plasma

from rat

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Synonym(s):
Citrated plasma
MDL number:
MFCD00131920
UNSPSC Code:
12352207
NACRES:
NA.71

biological source

rat

Quality Level

200

form

powder

contains

3.8% trisodium citrate as anticoagulant

storage temp.

2-8°C

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General description

Plasma is straw yellow in color and is the liquid portion of blood. The major component of plasma is water with solids accounting to 9%.

Biochem/physiol Actions

Plasma comprises many proteins that regulate various biological functions including electrolyte balance, transport and defense. Infusion of plasma by therapeutic plasmapheresis is useful in treating illness. However, at the same time it triggers allergic reactions.

Other Notes

This product is prepared from pooled rat blood. It contains 3.8% trisodium citrate as an anticoagulant. It is tested for clotting, which indicates that the clotting factors in the product are active. However, it is not analyzed to determine whether other enzymes present are native or denatured. The resulting plasma is 0.45 microm filtered and lyophilized from the indicated volume.

Preparation Note

Whole blood collected with anticoagulants (9:1), pooled, and centrifuged. The resulting plasma is 0.45 μm filtered and lyophilized from the indicated volumes.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. How is the rat plasma, Product No. P2516, reconstituted?

    The rat plasma should be reconstituted with deionized water to a final volume of 1.0 mL.  At this point, mix the solution gently.

  6. How do I store the rat plasma, Product No. P2516, after reconstitution?  

    After reconstitution, the plasma can be stored on ice for up to 8 hours.  Alternatively, aliquots can be made and stored at -20 degrees Celsius for up to one month.  Freezing the solution may cause the precipitation of serum proteins.

  7. Is the rat plasma, Product No. P2516, a sterile product?

    No, the plasma is filtered through  a 0.45 micrometer filter.  This removes particulates but it does not sterilize the plasma.

  8. Does this rat plasma, Product No. P2516, contain EDTA or heparin?

    Neither EDTA or heparin is used in the production of this rat plasma.

  9. What strains of rats are used in the production of the rat plasma, Product No. P2516?  Is this produced from male or female rats?

    A mixture of strains is used to produce this rat plasma.  The plasma is made from both male and female rats.

  10. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Plasma and Plasma proteins
Essentials of Medical physiology (2018)
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Clinical proteomics, 17, 33-33 (2020-09-24)
Verification of cerebrospinal fluid (CSF) biomarkers for multiple sclerosis and other neurological diseases is a major challenge due to a large number of candidates, limited sample material availability, disease and biological heterogeneity, and the lack of standardized assays. Furthermore, verification
Plasma and plasma derivatives in therapeutic plasmapheresis
McLeod, Bruce C
Transfusion, 52, 38S-44S (2012)
A I Potapovich et al.
British journal of pharmacology, 158(5), 1236-1247 (2009-09-30)
The immunomodulatory effects of alpha-fetoprotein (AFP) on lymphocytes and macrophages have been described in vitro and in vivo. Recombinant forms of human AFP have been proposed as potential therapeutic entities for the treatment of autoimmune diseases. We examined the effects

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