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Merck
CN

P2371

Pamidronate disodium salt hydrate

≥95% (NMR), Bone resorption inhibitor, solid

Synonym(s):

3-Amino-1-hydroxy-1-phosphonopropanephosphonic acid disodium salt hydrate

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About This Item

Empirical Formula (Hill Notation):
C3H9NO7P2Na2 · xH2O
CAS Number:
57248-88-1
Molecular Weight:
279.03 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
24724574
UNSPSC Code:
12352200
EC Number:
260-647-1
MDL number:
MFCD11045314

Key Documents

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Product Name

Pamidronate disodium salt hydrate, ≥95% (NMR), solid

InChI key

TVQNUQCYOOJTMK-UHFFFAOYSA-L

InChI

1S/C3H11NO7P2.2Na.H2O/c4-2-1-3(5,12(6,7)8)13(9,10)11;;;/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11);;;1H2/q;2*+1;/p-2

SMILES string

O.[Na+].[Na+].NCCC(O)(P(O)([O-])=O)P(O)([O-])=O

assay

≥95% (NMR)

form

solid

color

white

mp

300 °C

solubility

H2O: 28 mg/mL

originator

Novartis

storage temp.

2-8°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Bone resorption inhibitor; inhibitor of farnesyl diphosphate synthase (IC50 = 200 nM).
Pamidronate disodium has the ability to block Wnt and β-catenin signaling, which modulates the osteogenic differentiation in bone marrow mesenchymal stem cells (BMMSCs). It can also reduce bilirubin-impaired apoptosis and helps to develop dentinogenic dysfunction of stem cells from human deciduous teeth.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000514891
0000514889
0000514891
0000514889
0000427580

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Coralie Leblicq et al.
Pediatric blood & cancer, 60(5), 741-747 (2012-09-25)
Osteonecrosis (ON) is a severe complication of acute lymphoblastic leukemia (ALL) treatments. Recent studies suggest that bisphosphonates might reduce pain and loss of motor function in patients with ON. We assessed the effects of pamidronate compared to standard care in
Pamidronate Disodium Leads to Bone Necrosis via Suppression of Wnt/beta-Catenin Signaling in Human Bone Marrow Mesenchymal Stem Cells In Vitro
Xu Y, et al.
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 75(10), 2135-2143 (2017)
Pamidronate decreases bilirubin-impaired cell death and improves dentinogenic dysfunction of stem cells from human deciduous teeth
Yamaza H, et al.
Stem Cell Research & Therapy, 9(1), 303-303 (2018)
Eitan Amir et al.
American journal of clinical oncology, 36(5), 436-442 (2012-07-12)
Despite substantial variability in individual risk of skeletal complications, patients with metastatic bone disease are treated with bisphosphonates at the same dose and dosing interval. This study assessed the feasibility of conducting a randomized trial of less frequent bisphosphonate administration
Amber L Watters et al.
Oral surgery, oral medicine, oral pathology and oral radiology, 115(2), 192-200 (2012-10-06)
We report long-term follow-up of patients with intravenous bisphosphonate-related osteonecrosis of the jaw (BRONJ). Medical and dental histories, including type and duration of bisphosphonate treatment and comorbidities, were analyzed and compared with clinical course of 109 patients with BRONJ at
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