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Safety Information

P1782

Sigma-Aldrich

Protein kinase Cα isozyme human

≥70% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous glycerol solution

Synonym(s):

PKCα

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5 μG
CN¥4,526.72
20 μG
CN¥11,100.17

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5 μG
CN¥4,526.72
20 μG
CN¥11,100.17

About This Item

MDL number:
MFCD00241710
UNSPSC Code:
12352202
NACRES:
NA.32

CN¥4,526.72

Please contact Customer Service for Availability
New, lower price on this item!
Request a Bulk Order

recombinant

expressed in baculovirus infected insect cells

Assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

specific activity

≥250 units/μg protein

mol wt

80-81 kDa by SDS-PAGE

UniProt accession no.

P17252

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... PRKCA(5578)

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Protein kinase Cα isozyme human ≥70% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous glycerol solution

P1782

Protein kinase Cα isozyme human

Protein Kinase CβI isozyme human ≥95% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous glycerol solution

P1787

Protein Kinase CβI isozyme human

Protein Kinase Cδ isozyme human >95% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous glycerol solution

P8538

Protein Kinase Cδ isozyme human

Protein Kinase Cζ isozyme human ≥75% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous solution

P0194

Protein Kinase Cζ isozyme human

Gene Information

human ... PRKCA(5578)

Gene Information

human ... PRKCB(5579)

Gene Information

human ... PRKCD(5580)

Gene Information

human ... PRKCZ(5590)

assay

≥70% (SDS-PAGE)

assay

≥95% (SDS-PAGE)

assay

>95% (SDS-PAGE)

assay

≥75% (SDS-PAGE)

recombinant

expressed in baculovirus infected insect cells

recombinant

expressed in baculovirus infected insect cells

recombinant

expressed in baculovirus infected insect cells

recombinant

expressed in baculovirus infected insect cells

form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

form

buffered aqueous solution

UniProt accession no.

P17252

UniProt accession no.

P05771

UniProt accession no.

Q05655

UniProt accession no.

Q05513

Biochem/physiol Actions

PKCα enhances the proliferation of several tumor cell lines in vitro and in vivo. Increases permeability of endothelial and epithelial tight junctions.
Protein Kinase C (PKC) is a serine/threonine kinase that is activated intracellularly by signal transduction pathways that produce DAG from phosphatidylinositol diphosphate (PIP2) and phosphatidylcholine (PC) through the action of various activated phospholipases. Phorbol esters also stimulate PKC. At least 11 PKC isozymes have been identified that differ in primary structure, tissue distribution, subcellular localization, response to extracellular signals, and substrate specificity. The isozymes can be grouped into three subfamilies. Members of the first family require Ca2+ and phospholipid and include PKCα, βI, βII, and γ. Members of the second family are phospholipid-dependent but Ca2+-independent, and include PKCδ, ε, η, and θ. Members of the third family are not activated by either DAG or phorbol esters and include PKCξ, μ, and ι.
Phosphorylation appears to be an important mechanism of regulation of all PKCs. PKC plays a role in the regulation of cell transformation, growth, differentiation, ruffling, vesicle trafficking, apoptosis and gene expression.

Unit Definition

One unit will transfer 1 pmol of phosphate from ATP to Histone H1 in 1 minute at pH 7.4 at 30 °C

Physical form

Supplied as a buffered aqueous glycerol solution, containing Trizma buffer, NaCl, DTT and Glutathione.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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    0000278698
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    SLCN7111
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    Heidi Budde et al.
    Antioxidants (Basel, Switzerland), 10(7) (2021-08-07)
    Oxidative stress is defined as an imbalance between the antioxidant defense system and the production of reactive oxygen species (ROS). At low levels, ROS are involved in the regulation of redox signaling for cell protection. However, upon chronical increase in

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