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P1629

Sigma-Aldrich

TWEEN® 60

nonionic detergent

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Synonym(s):
Polyethylene glycol sorbitan monostearate, Polyoxyethylene sorbitan monostearate
CAS Number:
9005-67-8
MDL number:
MFCD01780110
UNSPSC Code:
12161900
NACRES:
NA.25

Quality Level

200

mol wt

estimated mol wt 1309

composition

stearic acid, 40-60%
total stearic and palmitic acid, ≥90%

technique(s)

DNA extraction: suitable
RNA extraction: suitable
cell culture | mammalian: suitable
protein purification: suitable

CMC

27 mg/L

density

1.044 g/mL at 25 °C (lit.)

HLB

14.9

InChI

1S/C26H50O10/c1-2-3-4-5-6-7-8-9-10-11-24(30)34-19-18-31-20-22(32-15-12-27)26-25(35-17-14-29)23(21-36-26)33-16-13-28/h22-23,25-29H,2-21H2,1H3

InChI key

HMFKFHLTUCJZJO-UHFFFAOYSA-N

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General description

TWEEN 60 is a niosome.

Application

Polyethylene glycol sorbitan monostearate, or TWEEN 60, has been used in a study to assess encapsulation of functional lipophilic components in surfactant-based colloidal delivery systems. It has also been used in a study to investigate doxorubicin loaded magneto-niosomes for targeted drug delivery.

Legal Information

TWEEN is a registered trademark of Croda International PLC

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Physicochemical properties and skin permeation of [TM="Span"] 60/Tween 60 niosomes of ellagic acid
Burapacheep, V., et al.
International Journal of Pharmaceutics, 432, 9-9 (2012)
Lorena Tavano et al.
Colloids and surfaces. B, Biointerfaces, 102, 803-807 (2012-10-31)
In chemotherapy the magnetic drug targeting to a specific organ or tissue is proposed on the assumption that magnetic fields are harmless to biological systems. In this light we have vehiculated doxorubicin as model drug by novel magneto-niosomes in order
Ray F David et al.
Fungal genetics and biology : FG & B, 96, 25-32 (2016-10-22)
The plant pathogenic ascomycete Fusarium graminearum produces perithecia on corn and small grain residues. These perithecia forcibly discharge ascospores into the atmosphere. Little is known about the relationship among the strength of the perithecial wall, the age of the perithecium
Khalid Ziani et al.
Food chemistry, 134(2), 1106-1112 (2012-10-31)
The fabrication and stability of surfactant-based colloidal delivery systems (microemulsions and emulsions) suitable for encapsulation of lipophilic active agents (vitamins and flavours) was investigated. An emulsion titration method was used to study the influence of surfactant type (Tween 20, 60
Rafaela C Sartore et al.
PloS one, 6(6), e20667-e20667 (2011-06-16)
The existence of loss and gain of chromosomes, known as aneuploidy, has been previously described within the central nervous system. During development, at least one-third of neural progenitor cells (NPCs) are aneuploid. Notably, aneuploid NPCs may survive and functionally integrate

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