P1618
Protein Phosphatase 2Ac from bovine kidney
buffered aqueous glycerol solution
Synonym(s):
PP2Ac
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About This Item
UNSPSC Code:
12352202
NACRES:
NA.32
Recommended Products
biological source
bovine kidney
Quality Level
Assay
≥90% (SDS-GE)
form
buffered aqueous glycerol solution
specific activity
~2 U/vial
mol wt
36 kDa
UniProt accession no.
application(s)
cell analysis
shipped in
dry ice
storage temp.
−70°C
Gene Information
bovine ... PPP2CA(282320)
General description
Protein phosphatase 2 catalytic subunit a (PPP2CA/PP2Ac) gene is mapped to human chromosome 5q31.1. The PPP2CA gene encodes the catalytic subunit of PP2A (protein phosphatase 2), a serine/threonine phosphatase.
Biochem/physiol Actions
Divalent cation-independent catalytic subunit of protein phosphatase 2A. Useful for functional studies of the A and B subunit of the phosphatase.
Protein phosphatase 2 catalytic subunit α (PPP2CA/PP2Ac) is a tumor suppressor and negatively regulates cell cycle. It mainly regulates PI3K (phosphatidylinositol 3-kinase)/AKT (RAC-α serine/threonine-protein kinase) pathway, MEK1 (MAPK/ERK kinase 1), ERK (extracellular signal-regulated kinase) family kinases and c-myc transcription factors.
Physical form
1 μg per vial in 50 μl of 50 mM Tris-HCl, pH 7.0, containing 14 mM β-Mercaptoethanol, 1mM benzamidine, 0.1 mM PMSF, 1mM EDTA, and 50% glycerol.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Skin Sens. 1
Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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MID1 catalyzes the ubiquitination of protein phosphatase 2A and mutations within its Bbox1 domain disrupt polyubiquitination of alpha4 but not of PP2Ac.
Du H, et al.
PLoS ONE null
Overexpression of PP2A inhibitor SET oncoprotein is associated with tumor progression and poor prognosis in human non-small cell lung cancer.
Liu H, et al.
Oncotarget, 14913-25 null
Myelodysplastic syndromes: an update on molecular pathology
Tormo M, et al.
Clinical And Translational Oncology, 652-61 null
Protein Phosphatase 2A Inhibition with LB100 Enhances Radiation-Induced Mitotic Catastrophe and Tumor Growth Delay in Glioblastoma
Gordon IK, et al.
Molecular Cancer Therapeutics, 1540-1547 null
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