P1306
Peptide YY human
≥97% (HPLC), synthetic
Synonym(s):
PYY, Tyr-Pro-Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Val-Thr-Arg-Gln-Arg-Tyr-NH2
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About This Item
Empirical Formula (Hill Notation):
C194H295N55O57
CAS Number:
Molecular Weight:
4309.75
MDL number:
UNSPSC Code:
51111800
NACRES:
NA.32
Amino Acid Sequence
Tyr-Pro-Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Val-Thr-Arg-Gln-Arg-Tyr-NH2
General description
Human peptide YY (PYY) is secreted by mucosal L cells in the distal ileum, colon and rectum. It consists of 36 amino acids. The gene encoding PYY is localized on human chromosome 17q21.1.
Application
Peptide YY human has been used as a supplement in Roswell Park Memorial Institute medium (RPMI medium) to culture pancreatic duct-derived cells.
Biochem/physiol Actions
Gut hormone that inhibits both secretin and cholecystokinin-stimulated pancreatic secretion. Endogenous nonselective agonist at NPY receptors.
Human peptide YY (PYY) has a role in food ingestion, gut motility and insulin secretion. The protein suppresses appetite. It has been associated with obesity and type 2 diabetes. PYY also has a role in energy homeostasis.
Other Notes
Lyophilized from 0.1% TFA in H2O
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
监管及禁止进口产品
Certificates of Analysis (COA)
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Find documentation for the products that you have recently purchased in the Document Library.
The Association of Serum Total Peptide YY (PYY) with Obesity and Body Fat Measures in the CODING Study.
Cahill F
PLoS ONE (2014)
TLR ligands and butyrate increase Pyy expression through two distinct but inter-regulated pathways.
Larraufie P
Cellular Microbiology (2017)
Genomic and gene expression signature of the pre-invasive
testicular carcinoma in situ
testicular carcinoma in situ
Kristian Almstrup
Cell and Tissue Research (2005)
Expression of peptide YY by human blood leukocytes.
Holler JP
Peptides (2014)
Rapid and Efficient In Vitro Generation of Pancreatic Islet
Progenitor Cells from Nonendocrine Epithelial Cells in the
Adult Human Pancreas
Progenitor Cells from Nonendocrine Epithelial Cells in the
Adult Human Pancreas
JOSEPHINE S. D?ALESSANDRO
Stem Cells and Development (2007)
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