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Merck
CN

P0928

Resorufin pentyl ether

≥98% (TLC), Fluorimetric Cytochrome P450 substrate, powder

Synonym(s):

7-Pentyloxy-3-phenoxazone, 7-Pentyloxy-3H-phenoxazin-3-one, O7-Pentylresorufin, Pentoxyresorufin

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About This Item

Empirical Formula (Hill Notation):
C17H17NO3
CAS Number:
87687-03-4
Molecular Weight:
283.32
NACRES:
NA.47
PubChem Substance ID:
24898138
UNSPSC Code:
12161501
MDL number:
MFCD00037664
Beilstein/REAXYS Number:
8394939

Key Documents

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Product Name

Resorufin pentyl ether,

InChI

1S/C17H17NO3/c1-2-3-4-9-20-13-6-8-15-17(11-13)21-16-10-12(19)5-7-14(16)18-15/h5-8,10-11H,2-4,9H2,1H3

SMILES string

CCCCCOc1ccc2N=C3C=CC(=O)C=C3Oc2c1

InChI key

ZPSOKQFFOYYPKC-UHFFFAOYSA-N

assay

≥98% (TLC)

form

powder

solubility

acetonitrile: 0.95- 1.05 mg/mL, clear, orange

storage temp.

2-8°C

Quality Level

200

Related Categories

General description

Resorufin pentyl ether is an analog of resazurin. Resorufin is a redox probe which is colorless and non-fluorescent in its reduced state. On oxidation, it fluoresces red. Resorufin is used widely as an indicator in microbiological media. It can be used to differentiate between actively metabolizing cells and inactive or dead cells.

Application

Resorufin pentyl ether has been used as a substrate to study the effects of Kaempferia parviflora extract on mouse hepatic cytochrome P450 enzymes.

Biochem/physiol Actions

Fluorimetric substrate for cytochrome P450 linked enzymes, CYP2B and CYP2B4.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000453977
0000453977
0000312734
0000312734
0000185060

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Canan Sapmaz et al.
Drug and chemical toxicology, 43(1), 13-21 (2018-05-19)
Morin is a flavonoid which is present in many plants. Endosulfan and 7,12-dimethylbenz[a]anthracene (DMBA) are toxic chemicals that humans are exposed to in their daily lives. In this study, the protective role of morin was investigated in endosulfan and DMBA
Antibacterial activity of resazurin-based compounds against Neisseria gonorrhoeae in vitro and in vivo
Deanna M
International Journal of Antimicrobial Agents (2016)
Jeroen Kool et al.
Drug metabolism and disposition: the biological fate of chemicals, 35(4), 640-648 (2007-01-26)
A high resolution screening (HRS) technology is described, in which gradient high-performance liquid chromatography (HPLC) is connected on-line to three parallel placed bioaffinity detection systems containing mammalian cytochromes P450 (P450s). The three so-called enzyme affinity detection (EAD) systems contained, respectively
R B van Breemen et al.
Drug metabolism and disposition: the biological fate of chemicals, 26(2), 85-90 (1998-03-28)
An on-line mass spectrometric method has been developed to generate and identify drug metabolites formed by hepatic cytochromes P450. This method, pulsed ultrafiltration-mass spectrometry, may be used for rapid screening of drugs to determine their extent of metabolism by microsomal
Aline Y O Matsuo et al.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 147(1), 78-84 (2007-09-11)
Wild stocks of Pacific salmon in the Northwestern United States have declined in recent years, and the major factors contributing to these losses include water pollution and loss of habitat. In salmon, sublethal chemical exposures may impact critical behaviors (such
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Articles

Phase I Drug Metabolism

Phase I biotransformation reactions increase drug compound polarity, mainly occurring in hepatic circulation.

一期药物代谢

一期生物转化反应在药物上引入或暴露官能团，目的是增加化合物的极性。尽管一期药物代谢发生在大多数组织中，但代谢的主要和首过部位发生在肝循环期间。

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