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Merck
CN

P0314

Prostaglandin F2α methyl ester

~5 mg/mL in methyl acetate, ≥95% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C21H36O5
CAS Number:
33854-16-9
Molecular Weight:
368.51
UNSPSC Code:
12352200
PubChem Substance ID:
24898094
EC Number:
201-185-2
MDL number:
MFCD00133790

Key Documents

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InChI key

KRDFNHLEMLCWKD-GWSKAPOCSA-N

InChI

1S/C22H38O5/c1-3-5-8-11-17(23)14-15-19-18(20(24)16-21(19)25)12-9-6-7-10-13-22(26)27-4-2/h6,9,14-15,17-21,23-25H,3-5,7-8,10-13,16H2,1-2H3/b9-6-,15-14+/t17-,18+,19+,20-,21+/m0/s1

SMILES string

CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(=O)OCC

assay

≥95% (HPLC)

concentration

~5 mg/mL in methyl acetate

storage temp.

−20°C

Biochem/physiol Actions

Constricts an isolated human smooth muscle; methyl ester form of prostaglandin F2α which is a luteolytic prostaglandin (induces parturition; pulmonary vasoconstrictor).

Packaging

Packaged under Argon.

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Danger

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

target_organs

Central nervous system

supp_hazards

EUH066

Storage Class

3 - Flammable liquids

wgk

WGK 2

flash_point_f

15.0 °F

flash_point_c

-9.45 °C

ppe

Eyeshields, Faceshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
040M1484
048K1134
117K1363
045K1742
045K1741

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B Wu et al.
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, 13(2), 177-180 (1997-05-01)
The effect of 15-Mt-PGF2 alpha on CCl4-induced injury of primary cultured hepatocytes was studied. 15-Mt-PGF2 alpha treatment (2 mg/L) significantly decreased CCl4 (10 mmol/L)-induced damages of primary cultured rat heptocytes as indicated by decreases GPT and GOT leakage and LPO
A Alm et al.
Progress in clinical and biological research, 312, 447-458 (1989-01-01)
A lipid-soluble PG ester such as PGF2 alpha-IE reduces IOP in the human eye when given in considerably lower doses than are needed for the tromethamine salt of this PG to do so. However, with the pharmaceutical composition now used
L Mastalerz
Polskie Archiwum Medycyny Wewnetrznej, 93(2), 179-183 (1995-02-01)
Prostaglandins (PGs) belong to the family of eicosanoids. A main substrate in their biosynthesis is arachidonic acid. Involvement of PGs in regulation of bronchial activity is a complex process and far from being fully understood. In 1968 it was shown
The ocular hypotensive effects and side effects of prostaglandins on the eyes of experimental animals.
L Z Bito et al.
Progress in clinical and biological research, 312, 349-368 (1989-01-01)
B V Praveen et al.
International journal of clinical pharmacology, therapy, and toxicology, 30(1), 7-12 (1992-01-01)
A prospective randomized, controlled study was done to compare the efficacy and safety of 15(s) 15 Me PGF2 alpha intravesical instillation and 1% alum vesical irrigation in the control of vesical hematuria which persisted even after continuous bladder irrigation with
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