P0314
Prostaglandin F2α methyl ester
~5 mg/mL in methyl acetate, ≥95% (HPLC)
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About This Item
Empirical Formula (Hill Notation):
C21H36O5
CAS Number:
Molecular Weight:
368.51
EC Number:
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
Recommended Products
Assay
≥95% (HPLC)
concentration
~5 mg/mL in methyl acetate
storage temp.
−20°C
SMILES string
CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(=O)OCC
InChI
1S/C22H38O5/c1-3-5-8-11-17(23)14-15-19-18(20(24)16-21(19)25)12-9-6-7-10-13-22(26)27-4-2/h6,9,14-15,17-21,23-25H,3-5,7-8,10-13,16H2,1-2H3/b9-6-,15-14+/t17-,18+,19+,20-,21+/m0/s1
InChI key
KRDFNHLEMLCWKD-GWSKAPOCSA-N
Biochem/physiol Actions
Constricts an isolated human smooth muscle; methyl ester form of prostaglandin F2α which is a luteolytic prostaglandin (induces parturition; pulmonary vasoconstrictor).
Packaging
Packaged under Argon.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
Target Organs
Central nervous system
Supplementary Hazards
Storage Class Code
3 - Flammable liquids
WGK
WGK 2
Flash Point(F)
15.0 °F
Flash Point(C)
-9.45 °C
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Y Goh et al.
Japanese journal of ophthalmology, 32(4), 471-480 (1988-01-01)
Studies were carried out of the effects of topically applied prostaglandin (PG) D2 and its metabolites and analogues on the intraocular pressure (IOP) in rabbits, and the results were compared with those of studies using PGE2 and F2 alpha. The
L Z Bito
Experimental eye research, 38(2), 181-194 (1984-02-01)
It has recently been shown that prostaglandin (PG)E2 or F2 alpha reduces the intraocular pressure (IOP) of cats and primates when applied topically to the eye in very small doses, and that reduced IOP can be maintained in these species
J Rydnert
Acta obstetricia et gynecologica Scandinavica, 65(2), 175-180 (1986-01-01)
The hysterometric technique has been designed to measure the pharmacological effect of active agents upon the human uterine muscle. The physiological background is the fact that smooth muscle contracts under the influence of mechanical stimulation. By applying hysterometry, the effects
Mucha et al.
Prostaglandins, leukotrienes, and essential fatty acids, 65(5-6), 271-280 (2002-05-08)
This paper describes a new iodine-125 radioimmunoassay of 9alpha ,11beta-PGF2, and its use for the determination of urinary 9alpha,11beta-prostaglandin F2 after a selective one-step solid-phase extraction. The newly reported immunoassay is based on the use of 125I-tyrosyl methyl ester derivative
R N Prasad et al.
The Australian & New Zealand journal of obstetrics & gynaecology, 35(1), 52-54 (1995-02-01)
Prostaglandin analogues have proven to be safe and effective for second trimester pregnancy terminations when given by various routes. Of these, the intra-amniotic (IA) route has proven to be safer, especially in women with medical disorders, as it causes the
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