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P0275

Sigma-Aldrich

Poly(Glu, Tyr) sodium salt

greener alternative

Glu:Tyr (4:1), mol wt 20,000-50,000

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Synonym(s):
L-Glutamic acid sodium salt (1:1) polymer with L-tyrosine
CAS Number:
97105-00-5
MDL number:
MFCD00148022
UNSPSC Code:
12352209
NACRES:
NA.26

form

powder

Quality Level

200

feed ratio

Glu:Tyr (4:1)

mol wt

20,000-50,000

greener alternative product score

old score: 48
new score: 45
Find out more about DOZN™ Scoring

greener alternative product characteristics

Safer Solvents and Auxiliaries
Design for Energy Efficiency
Reduce Derivatives
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

color

white to off-white

greener alternative category

, Re-engineered

storage temp.

−20°C

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General description

We are committed to bringing you Greener Alternative Products, which adhere to one of the four categories of Greener Alternatives . This product belongs to category of Re-engineered products, showing key improvements in Green Chemistry Principles “Safer Solvents and Auxiliaries”, “Enhanced Energy Efficiency” and “Reduced Derivative”. Click here to view its DOZN scorecard.

Application

Poly(Glu, Tyr) sodium salt has been used as a substrate for
  • janus kinase 3 (JAK3) in enzyme linked immunosorbent assay (ELISA)-based assay
  • proto-oncogene tyrosine-protein kinase (Src) and zeta chain of T cell receptor associated protein kinase 70 (Zap70)
  • in in vitro tyrosine kinase assay

Biochem/physiol Actions

Poly(glu, tyr) sodium salt is a polyamino acid with applications in cancer research.

Analysis Note

Molecular weight based on viscosity. Also assayed by MALLS.

Other Notes

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Identification of Chinese Herbal Compounds with Potential as JAK3 Inhibitors
Su D, et al.
Evidence-Based Complementary and Alternative Medicine : ECAM (2019)
Dimerization of the Pragmin pseudo-kinase regulates protein tyrosine phosphorylation
Lecointre C, et al.
Structure, 26(4), 545-554 (2018)
A simple and robust automated kinase profiling platform using luminescent ADP accumulation technology
Larson B, et al.
Assay and Drug Development Technologies, 7(6), 573-584 (2009)
C J Bruns et al.
Cancer research, 60(11), 2926-2935 (2000-06-13)
We determined whether down-regulation of the epidermal growth factor-receptor (EGF-R) signaling pathway by oral administration of a novel EGF-R tyrosine kinase inhibitor (PKI166) alone or in combination with gemcitabine (administered i.p.) can inhibit growth and metastasis of human pancreatic carcinoma
Jiaye Guo et al.
Biochemistry, 57(32), 4934-4951 (2018-07-06)
Human epidermal growth factor receptor 2 (HER2) is a validated breast cancer drug target for small molecule inhibitors that target the ATP-binding pocket of the kinase domain. In this work, a large-scale virtual screen was performed to a novel homology
View All Related Papers

Articles

Poly(Amino Acid) Block Copolymers for Drug Delivery and other Biomedical Applications

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