P0270
Calmodulin from bovine heart
lyophilized powder, 2,500-10,000 units/mg protein
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Synonym(s):
Phosphodiesterase 3′:5′-cyclic nucleotide activator from bovine heart
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biological source
bovine heart
Quality Level
form
lyophilized powder
specific activity
2,500-10,000 units/mg protein
composition
Protein, ≥85% Lowry
technique(s)
calcium flux assay: suitable
UniProt accession no.
storage temp.
−20°C
Gene Information
cow ... CALM3(520277)
Related Categories
Application
This is the protein activator required for the Ca2+ dependent activation of phosphodiesterase, 3′:5′-cyclic nucleotide, P0520.
Biochem/physiol Actions
Ca2+ binding protein that is required for activation of cyclic nucleotide-dependent phosphodiesterase. It is also a cofactor/activator of nitric oxide synthase, calcineurin, and many kinases including ATPase, myosin light chain kinase, and CAM kinase I, II, and III. It mediates ryanodine receptor activation by cyclic ADP ribose and is involved in intracellular Ca2+ homeostasis.
Unit Definition
One unit will stimulate 0.008 activated unit of phosphodiesterase, 3′:5′-cyclic nucleotide, P0520, in a 3 mL reaction volume at pH 7.5 and 30 °C, to 50% of the maximum activity of the enzyme when saturated with activator, in the presence of 0.01 mM Ca2+.
Physical form
Lyophilized powder containing buffer salts as imidazole and magnesium sulfate
Preparation Note
Purified by a modification of the procedure of Teo, T.S., et al., J. Biol. Chem., 248, 588 (1973).
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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