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Safety Information

P0048

Sigma-Aldrich

Pemoline

≥98% (HPLC)

Synonym(s):

2-Amino-5-phenyl4(5H)-oxazolone, Phenylisohydantoin

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About This Item

Empirical Formula (Hill Notation):
C9H8N2O2
CAS Number:
2152-34-3
Molecular Weight:
176.17
EC Number:
218-438-8
MDL number:
MFCD00083197
UNSPSC Code:
12352200
PubChem Substance ID:
329819998
NACRES:
NA.77

Assay

≥98% (HPLC)

form

solid

drug control

USDEA Schedule IV; Home Office Schedule 4.2; psychotrope (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)

solubility

DMSO: 28 mg/mL

originator

Boehringer Ingelheim

storage temp.

2-8°C

SMILES string

NC1=NC(=O)C(O1)c2ccccc2

InChI

1S/C9H8N2O2/c10-9-11-8(12)7(13-9)6-4-2-1-3-5-6/h1-5,7H,(H2,10,11,12)

InChI key

NRNCYVBFPDDJNE-UHFFFAOYSA-N

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Biochem/physiol Actions

Pemoline is a CNS stimulant.
Pemoline is a CNS stimulant. Pemoline is used to treat attention-deficit hyperactivity disorder (ADHD). Pemoline is a Schedule IV drug and offers some advantages over other stimulants in that it does not reduce the appetite or cause dry mouth.

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302 + H312 + H332

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
029K4630

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Gideon Koren et al.
Handbook of experimental pharmacology, 205, 169-180 (2011-09-02)
It typically takes many years before an association of a drug with a rare, serious adverse reaction is established. As related to pediatric drug use, evidence is even more erratic, as most drugs are used off labels. To enhance child
Darragh P Devine
Methods in molecular biology (Clifton, N.J.), 829, 155-163 (2012-01-11)
Traditional models of neuropsychiatric disorders consist of attempts to replicate the broad spectrum of behavioural and neurochemical sequelae that characterize a specific disorder. However, these disorders comprise complex constellations of symptoms, including emotional instability, perseverative thoughts, and aberrant behaviours. Close
Scott P Novak et al.
Substance abuse treatment, prevention, and policy, 2, 32-32 (2007-11-02)
Emerging evidence suggests that nonmedical use (NMU) of prescription attention deficit/hyperactivity disorder (ADHD) medications is rising, but many previous investigations have used clinical or regionally based samples or limited their investigations to stimulants rather than to medications specifically used to
Coming into focus. Pharmacologic treatment for ADHD.
Mary Ann McDonnell et al.
Advance for NPs & PAs, 1(4), 16-22 (2011-02-16)
Steven C Marcus et al.
Journal of the American Academy of Child and Adolescent Psychiatry, 50(5), 480-489 (2011-04-26)
This analysis assessed whether stimulant adherence was associated with improvement in academic grade point average (GPA) among children diagnosed with and treated for attention-deficit/hyperactivity disorder (ADHD). Medicaid claims were merged with academic records from Philadelphia public schools of Medicaid-eligible children
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