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P0038

Sigma-Aldrich

Paeoniflorin

≥98% (HPLC)

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Synonym(s):
NSC 178886, Peoniflorin
Empirical Formula (Hill Notation):
C23H28O11
CAS Number:
23180-57-6
Molecular Weight:
480.46
EC Number:
245-476-2
MDL number:
MFCD00869331
UNSPSC Code:
12352201
PubChem Substance ID:
329819989
NACRES:
NA.25

biological source

plant (Paeonia Albiflora)

Quality Level

100

Assay

≥98% (HPLC)

form

powder

technique(s)

HPLC: suitable

impurities

<3.0% water (Karl Fischer)

color

white

solubility

water: insoluble

storage temp.

2-8°C

SMILES string

C[C@@]12C[C@@]3(O)O[C@@H](O1)[C@]5(COC(=O)c4ccccc4)[C@H]3C[C@]25O[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O

InChI

1S/C23H28O11/c1-20-9-22(29)13-7-23(20,32-18-16(27)15(26)14(25)12(8-24)31-18)21(13,19(33-20)34-22)10-30-17(28)11-5-3-2-4-6-11/h2-6,12-16,18-19,24-27,29H,7-10H2,1H3/t12-,13-,14-,15+,16-,18+,19-,20+,21+,22-,23+/m1/s1

InChI key

YKRGDOXKVOZESV-WRJNSLSBSA-N

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General description

Paeoniflorin has been demonstrated to exert anti-inflammatory and immunomodulatory effects.

Application

Paeoniflorin was used to treat rats with collagen-induced arthritis in a study to assess the pro-apoptotic effect of Epigallo-catechin-3-gallate on B lymphocytes.

Biochem/physiol Actions

Herbal constituent of peony root. It is used in Chinese traditional medicine for its spasmolytic and pain-relieving properties. Exhibits anticoagulant, neuromuscular blocking, cognition-enhancing, immunoregulating, and antihyperglycemic effects.

Other Notes

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Wei Zhang et al.
International immunopharmacology, 14(1), 27-31 (2012-06-19)
Paeonia lactiflora Pallas, also named Chinese Paeony, is a Chinese herb. A decoction of its root has been used to treat painful or inflammatory disorders in traditional Chinese medicine. A water/ethanol extract of Radix Paeoniae is known as total glycosides
Di Wang et al.
International immunopharmacology, 14(2), 172-178 (2012-07-28)
Paeoniflorin has been demonstrated to exert anti-inflammatory and immunomodulatory effects in the animal study. The purpose of the present study was to investigate the effect of paeoniflorin on the recombinant human interleukin-1β (rhIL-1β)-stimulated monocytes from the peripheral blood of healthy
Jian-Zhe Li et al.
Canadian journal of physiology and pharmacology, 90(12), 1569-1575 (2012-12-06)
Increased intracellular reactive oxygen species (ROS) are involved in doxorubicin (DOX)-induced myocardial cell apoptosis, and paeoniflorin (PEF) has been shown to exert an antioxidant effect. The aim of the present study was to explore the protective effect of PEF on
Hitomi Hino et al.
PloS one, 7(8), e42920-e42920 (2012-08-24)
Febrile seizures (FS) is the most common convulsive disorder in children, but there have been no clinical and experimental studies of the possible treatment of FS with herbal medicines, which are widely used in Asian countries. Paeoniflorin (PF) is a
Naglaa Fathy Abd El-Aal et al.
Experimental parasitology, 197, 85-92 (2018-11-12)
Chronic hepatic schistosomiasis causes portal hypertension, fibrosis and lethal hepatosplenic complications. Previous studies focused mainly on schistosomicidal drugs and neglected the therapeutic approaches against the vascular complications after portal hypertension. Investigating a novel anti-angiogenic therapy is an urgent. The current
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