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Safety Information

P0021

Sigma-Aldrich

Pantoprazole sodium hydrate

≥98% (HPLC)

Synonym(s):

5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole sodium salt hydrate, Pantozol hydrate, Protonix hydrate

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About This Item

Empirical Formula (Hill Notation):
C16H14F2N3O4S · Na · xH2O
CAS Number:
718635-09-7
Molecular Weight:
405.35 (anhydrous basis)
UNSPSC Code:
12352203
PubChem Substance ID:
329819976
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

color

white to off-white

solubility

H2O: ≥20 mg/mL

originator

Novartis

storage temp.

−20°C

SMILES string

O.[Na+].COc1ccnc(CS(=O)c2nc3cc(OC(F)F)ccc3[n-]2)c1OC

InChI

1S/C16H14F2N3O4S.Na.H2O/c1-23-13-5-6-19-12(14(13)24-2)8-26(22)16-20-10-4-3-9(25-15(17)18)7-11(10)21-16;;/h3-7,15H,8H2,1-2H3;;1H2/q-1;+1;

InChI key

CGJRLPRCWSHOFU-UHFFFAOYSA-N

Gene Information

human ... ATP4A(495) , ATP4B(496)

Related Categories

Application

Pantoprazole sodium hydrate has been used:
  • as a standard in high-performance liquid chromatography (HPLC){58
  • as a prazole to study its effects on prodrug activation and human immunodeficiency virus 1 (HIV-1) inhibition
  • to study its effects on breast cancer resistance protein (BCRP) inhibitors in various in vitro membrane preparations from various cell lines

Biochem/physiol Actions

Pantoprazole has the potential to treat symptoms of heartburn and acid regurgitation. It also has been studied to treat Helicobacter pylori infection and duodenal ulcer.
Pantoprazole is a benzimidazole derivative,activated in acidic environment. It is useful in treating long term prophylaxis and acid-related disorders.
Pantoprazole is a gastric proton pump inhibitor.

Features and Benefits

This compound is featured on the Acid-Sensing (Proton-gated) Ion Channels (ASICs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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<BIG>Rissling O</BIG>
Interaction of Mycophenolic Acid and Pantoprazole: A Pharmacokinetic Crossover Study (2017)
Analysis of ibuprofen, pantoprazole, and itopride combination therapeutic drugs in human plasma by solid phase membrane microtip extraction and high-performance liquid chromatography methods using new generation core shell C18 column
Ali I, et al.
Journal of Liquid Chromatography and Related Technologies, 39(7), 339-345 (2016)
Pantoprazole
<BIG>Perry CM and Ibbotson T</BIG>
Drugs, 101-132 (2003)
A Fitton et al.
Drugs, 51(3), 460-482 (1996-03-01)
Pantoprazole is an irreversible proton pump inhibitor which, at the therapeutic dose of 40mg, effectively reduces gastric acid secretion. In controlled clinical trials, pantoprazole (40mg once daily) has proved superior to ranitidine (300mg once daily or 150mg twice daily) and
Susan M Watanabe et al.
Scientific reports, 10(1), 4003-4003 (2020-03-07)
Two proton pump inhibitors, tenatoprazole and esomeprazole, were previously shown to inhibit HIV-1 egress by blocking the interaction between Tsg101, a member of the ESCRT-I complex, and ubiquitin. Here, we deepen our understanding of prazole budding inhibition by studying a
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