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OGS2891

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PSF-OXB20-COOH-TEV-FLAG®-6HIS - C-TERMINAL 6 HIS AND FLAG® DUAL TAG BACTERIAL PLASMID

plasmid vector for molecular cloning

Synonym(s):

cloning vector, expression vector, molecular cloning vector, plasmid, plasmid vector, snapfast vector, vector

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About This Item

UNSPSC Code:
12352200

recombinant

expressed in E. coli

tag

6-His tagged
FLAG® tagged

form

buffered aqueous solution

mol wt

size 3917 bp

bacteria selection

kanamycin

Origin of replication

pUC (500 copies)

Peptide cleavage

TEV

Peptide tag location

C-terminal

Promoter

Promoter name: OXB20
Promoter activity: constitutive
Promoter type: bacterial

reporter gene

none

shipped in

ambient

storage temp.

−20°C

General description

PSF-OXB20-COOH-TEV-FLAG® -6HIS - C-terminal 6 HIS AND FLAG® dual tag bacterial plasmid is designed to express tagged proteins in E. coli. The plasmid contains a constitutive promoter (OXB20) derived from the region upstream of the E. coli RecA gene. It does not require induction or any additional components for activity. It is the strongest of the bacterial promoters that we provide and this high level of expression can cause expression problems with some proteins with poor solubility. For this reason we sell a range of bacterial promoters with different expression levels (OXB1(low)>OXB20(high)) that can be provided with the peptide tags in this plasmid on request.

About the Peptide Tag:This plasmid contains a c-terminal FLAG epitope tag that can be fused to a gene of interest to allow protein detection and/or purification. The sequence of the tag is: DYKDDDDK. This plasmid also contains a secondary Hexa-Histidine (6His) tag protein tag. The sequence of this tag is: HHHHHHWe provide a range of dual peptide tag plasmids. This is because some peptide tags provide specific biological properties (e. g., small molecule affinity new epitopes solubility or protein secretion) that are not provided by others.

About the Cleavage Tag: PSF-OXB20-COOH-TEV-FLAG®-6HIS - C-terminal 6 HIS AND FLAG® dual tag bacterial plasmid lso encodes a protease cleavage site that is designed to be positioned between your gene of interest and the tag to allow the removal of the tag following protein purification or isolation. This plasmid contains a TEV cleavage tag. The protein sequence of the cleavage tag is: ENLYFQG. Cleavage occurs between the Glu and Gly residues. TEV is often reported to have better specificity for its recognition site compared to EKT Thrombin or Faxtor Xa.

Promoter Expression Level: This plasmid vector contains a constitutive bacterial promoter that does not require induction. It is the strongest bacterial promoter we sell and this can cause solubility and expression problems with some proteins. We also offer a range of other bacterial promoters that are compatible with this plasmid and are available on request.

PSF-OXB20-COOH-TEV-FLAG® -6HIS - C-terminal 6 HIS AND FLAG® dual tag bacterial plasmid is a C-terminal 6His and FLAG dual affinity and epitope tag bacterial expression plasmid. This plasmid vector allows the creation of tagged proteins with a TEV cleavage tag.

Sequence

To view sequence information for this product, please visit the product page

Analysis Note

To view the Certificate of Analysis for this product, please visit www.oxgene.com

Legal Information

F-127 is a registered trademark of BASF SE
FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

12 - Non Combustible Liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

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