O6254
(R)-(−)-2-Oxothiazolidine-4-carboxylic acid
≥98% (titration), suitable for plant cell culture
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Synonym(s):
L-(−)-2-Oxothiazolidine-4-carboxylic acid
Empirical Formula (Hill Notation):
C4H5NO3S
CAS Number:
Molecular Weight:
147.15
Beilstein:
4179169
MDL number:
UNSPSC Code:
12352106
PubChem Substance ID:
NACRES:
NA.26
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Quality Level
Assay
≥97% (TLC)
≥98% (titration)
form
(powder to crystals)
technique(s)
cell culture | plant: suitable
color
white to off-white
SMILES string
OC(=O)[C@@H]1CSC(=O)N1
InChI
1S/C4H5NO3S/c6-3(7)2-1-9-4(8)5-2/h2H,1H2,(H,5,8)(H,6,7)/t2-/m0/s1
InChI key
BMLMGCPTLHPWPY-REOHCLBHSA-N
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Related Categories
Application
- Artificial elevation of glutathione contents in salicylic acid-deficient tobacco (Nicotiana tabacum cv. Xanthi NahG) reduces susceptibility to the powdery mildew pathogen Euoidium longipes.: This study explores the impact of enhanced glutathione levels on resistance to powdery mildew in tobacco plants deficient in salicylic acid, indicating a potential application of R-(−)-2-Oxothiazolidine-4-carboxylic acid in managing plant diseases (Künstler et al., 2020).
Biochem/physiol Actions
2-Oxothiazolidine-4-carboxylic acid augments glutathione and cysteine production.
WGK
WGK 3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Abderrahim Nemmar et al.
Toxicology, 263(2-3), 84-92 (2009-06-30)
Inhaled particulate matter is associated with increased cerebro- and cardiovascular events. However, the systemic mechanisms underlying these effects remain unclear. In the present study, we investigated the mechanisms underlying the relationship between airway and systemic inflammation and pial cerebral venular
Xian Fan et al.
Alcoholism, clinical and experimental research, 35(10), 1866-1875 (2011-05-17)
Alcohol abuse and HIV-1 infection frequently coexist, and these individuals are at high risk for serious lung infections and respiratory failure. Although alcohol ingestion and HIV-1 transgene expression have been shown to independently cause oxidative stress and disrupt alveolar epithelial
M J Clemente-Moreno et al.
Plant biology (Stuttgart, Germany), 12(1), 88-97 (2010-07-27)
The effect of treatment with benzothiadiazole (BTH) or l-2-oxothiazolidine-4-carboxylic acid (OTC), and their interaction with Plum pox virus (PPV) infection, on antioxidative metabolism of pea plants was studied at the subcellular level. PPV infection produced a 20% reduction in plant
Anna B Ohlsson et al.
Plant physiology and biochemistry : PPB, 46(7), 655-664 (2008-06-06)
We have earlier shown that nicotinamide (NIC) and nicotinic acid (NiA) can induce defence-related metabolism in plant cells; e.g. increase the level of glutathione. Here we investigated if NIC and NiA could increase the metal tolerance in metal sensitive clones
Leonardo F Ferreira et al.
Journal of applied physiology (Bethesda, Md. : 1985), 107(1), 211-216 (2009-05-02)
Fatiguing exercise promotes oxidation of intracellular thiols, notably glutathione. Interventions that oppose or reverse thiol oxidation can inhibit fatigue. The reduced cysteine donor l-2-oxothiazolidine-4-carboxylate (OTC) supports glutathione synthesis and is approved for use in humans but has not been evaluated
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