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O5636

Sigma-Aldrich

9,12-Octadecadiynoic acid

≥98%

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Synonym(s):
ODYA, Ro 3-1314
Empirical Formula (Hill Notation):
C18H28O2
CAS Number:
2012-14-8
Molecular Weight:
276.41
MDL number:
MFCD00797685
UNSPSC Code:
12352106
PubChem Substance ID:
329818915
NACRES:
NA.77

Quality Level

200

Assay

≥98%

form

crystalline

mp

45-46 °C

solubility

water: slightly soluble

shipped in

wet ice

storage temp.

−20°C

SMILES string

CCCCCC#CCC#CCCCCCCCC(O)=O

InChI

1S/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-5,8,11-17H2,1H3,(H,19,20)

InChI key

KDYILQLPKVZDGB-UHFFFAOYSA-N

Biochem/physiol Actions

Potent cyclooxygenase and lipoxygenase inhibitor.

Caution

Oxygen and light sensitive.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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M Hitchcock et al.
British journal of pharmacology, 72(4), 689-695 (1981-04-01)
1. 5,8,11,14-Eicosatetraynoic acid (ETYA) inhibited the antigen-induced contractions of tracheal spirals obtained from actively sensitized guinea-pigs. Consistent data were obtained only when the spirals were treated with indomethacin. 2. ETYA did not affect histamine-induced contractions of indomethacin-treated tracheal spirals. 3.
Ning Wang et al.
Frontiers in physiology, 9, 583-583 (2018-06-08)
Background: Perivascular adipose tissue (PVAT) exerts anti-contractile effects on visceral arteries by release of various perivascular relaxing factors (PVRFs) and opening voltage-gated K+ (Kv) channels in vascular smooth muscle cells (VSMCs). Palmitic acid methyl ester (PAME) has been proposed as
David R Colquhoun et al.
Proteomics, 15(12), 2066-2077 (2015-04-29)
Protein acylation plays a critical role in protein localization and function. Acylation is essential for human immunodeficiency virus 1 (HIV-1) assembly and budding of HIV-1 from the plasma membrane in lipid raft microdomains and is mediated by myristoylation of the

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