O5250
D-Ornithine monohydrochloride
~98%
Synonym(s):
(R)-2,5-Diaminopentanoic acid monohydrochloride
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About This Item
Empirical Formula (Hill Notation):
C5H12N2O2 · HCl
CAS Number:
Molecular Weight:
168.62
NACRES:
NA.26
PubChem Substance ID:
UNSPSC Code:
12352209
EC Number:
240-729-3
MDL number:
Beilstein/REAXYS Number:
4153339
Product Name
D-Ornithine monohydrochloride, ~98%
InChI key
GGTYBZJRPHEQDG-PGMHMLKASA-N
InChI
1S/C5H12N2O2.ClH/c6-3-1-2-4(7)5(8)9;/h4H,1-3,6-7H2,(H,8,9);1H/t4-;/m1./s1
SMILES string
Cl[H].NCCC[C@@H](N)C(O)=O
assay
~98%
form
powder
color
white
mp
239 °C
Quality Level
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Biochem/physiol Actions
D-Ornithine cleave proteins at cysteine residues.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Susan E Cellitti et al.
Nature chemical biology, 7(8), 528-530 (2011-04-29)
D-ornithine has previously been suggested to enhance the expression of pyrrolysine-containing proteins. We unexpectedly discovered that uptake of D-ornithine results in the insertion of a new amino acid, pyrroline-carboxy-lysine (Pcl) instead of the anticipated pyrrolysine (Pyl). Our feeding and biochemical
Sherry Dadsetan et al.
Biochemical pharmacology, 85(1), 115-123 (2012-10-30)
Combined administration of ornithine and phenylacetate (OP) is proposed as a novel treatment of hyperammonemia and hepatic encephalopathy. Ornithine is believed to increase ammonia fixation into glutamine in muscle tissue and glutamine is subsequently thought to react with phenylacetate forming
Nicole Berthold et al.
Antimicrobial agents and chemotherapy, 57(1), 402-409 (2012-11-02)
Proline-rich antimicrobial peptides (PrAMPs) from insects and mammals have recently been evaluated for their pharmaceutical potential in treating systemic bacterial infections. Besides the native peptides, several shortened, modified, or even artificial sequences were highly effective in different murine infection models.
Charles D Mills
Critical reviews in immunology, 32(6), 463-488 (2013-02-23)
The purpose of immunology is simple. Cure or prevent disease. M1/M2 is useful because it is simple. M1/M2 describes the two major and opposing activities of macrophages. M1 activity inhibits cell proliferation and causes tissue damage while M2 activity promotes
D Amelio et al.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 164(2), 356-362 (2012-11-06)
The Frank-Starling law is a fundamental property of the vertebrate myocardium which allows, when the end-diastolic volume increases, that the consequent stretch of the myocardial fibers generates a more forceful contraction. It has been shown that in the eel (Anguilla
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