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O4389

Sigma-Aldrich

Anti-Oxytocin Receptor antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

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Synonym(s):
Oxytocin Receptor Antibody, Oxytocin Receptor Antibody - Anti-Oxytocin Receptor antibody produced in rabbit
MDL number:
MFCD06798477
UNSPSC Code:
12352203

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 9 μg/mL using human prostate, glandular epithelium

UniProt accession no.

P30559

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... OXTR(5021)
mouse ... Oxtr(18430)
rat ... Oxtr(25342)

Immunogen

synthetic peptide corresponding to the N-terminal extracellular domain of human oxytocin receptor. The immunizing peptide has 95% homology with the rat and mouse gene.

Application

Anti-Oxytocin Receptor antibody produced in rabbit was used in immunoblotting analysis of proteins extracted from bovine T lymphocytes.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)

Biochem/physiol Actions

Oxytocin is a nonapeptide hormone that influences the social behavior in mammals that live in groups. Oxytocin binds to oxytocin receptor (OXTR) and regulates the ability to socially communicate and comprehend vocal communication. Polymorphisms in gene that codes of this receptor are associated with the severity of communication defects commonly observed in autism.

Physical form

Solution in phosphate buffered saline containing 0.1% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Brian W Haas et al.
Frontiers in human neuroscience, 7, 801-801 (2013-12-19)
Although cooperation represents a core facet of human social behavior there exists considerable variability across people in terms of the tendency to cooperate. One factor that may contribute to individual differences in cooperation is a key gene within the oxytocin
Frontiers in oxytocin science: from basic to practice.
Idan Shalev et al.
Frontiers in neuroscience, 7, 250-250 (2014-01-07)
Kalidou Ndiaye et al.
Biology of reproduction, 78(4), 786-793 (2007-12-21)
The corpus luteum (CL) produces oxytocin (OXT), which has been proposed to regulate the pulsatile release of prostaglandin F2alpha during luteolysis in ruminants. This action of OXT is mediated via oxytocin receptors (OXTRs) present on uterine epithelial cells. It is
A Annandale et al.
Theriogenology, 120, 1-9 (2018-08-04)
Persistent breeding-induced endometritis (PBIE) or delayed uterine clearance (DUC) are major causes of mare subfertility. Oxytocin and its receptor are thought to play significant roles in the pathogenesis of DUC but the specific roles of oxytocin receptor (OR) distribution and

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