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Merck
CN

O3251

Oxytocin

Synonym(s):

α-Hypophamine, Oxytocic hormone

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About This Item

Empirical Formula (Hill Notation):
C43H66N12O12S2
CAS Number:
50-56-6
Molecular Weight:
1007.19
UNSPSC Code:
51111800
NACRES:
NA.32
PubChem Substance ID:
24897975
EC Number:
200-048-4
Beilstein/REAXYS Number:
3586108
MDL number:
MFCD00076731
Biological source:
synthetic (organic)
Form:
lyophilized powder
Assay:
≥97% (HPLC)

Key Documents

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InChI key

XNOPRXBHLZRZKH-DSZYJQQASA-N

InChI

1S/C43H66N12O12S2/c1-5-22(4)35-42(66)49-26(12-13-32(45)57)38(62)51-29(17-33(46)58)39(63)53-30(20-69-68-19-25(44)36(60)50-28(40(64)54-35)16-23-8-10-24(56)11-9-23)43(67)55-14-6-7-31(55)41(65)52-27(15-21(2)3)37(61)48-18-34(47)59/h8-11,21-22,25-31,35,56H,5-7,12-20,44H2,1-4H3,(H2,45,57)(H2,46,58)(H2,47,59)(H,48,61)(H,49,66)(H,50,60)(H,51,62)(H,52,65)(H,53,63)(H,54,64)/t22-,25-,26-,27-,28-,29-,30-,31-,35-/m0/s1

SMILES string

[H]N[C@H]1CSSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O)[C@@H](C)CC)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O

biological source

synthetic (organic)

sterility

non-sterile

assay

≥97% (HPLC)

form

lyophilized powder

UniProt accession no.

P01178
P30559
P70536

shipped in

ambient

storage temp.

2-8°C

Quality Level

200

Gene Information

human ... OXT(5020), OXTR(5021)
rat ... Oxtr(25342)

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Application

Oxytocin has been used in experimental study to induce uterine contractions in rats. It has been used in comet assay to determine the number of cells with DNA damage.

Biochem/physiol Actions

Oxytocin (OXT) and arginine vasopressin hormone plays a vital role in regulation of water excretion, parturition and lactation. OXT has been implicated in hydromineral homeostasis and vascular and cardiac relaxation. Oxytocin might function as an effective therapeutic for psychiatric diseases, including depression, schizophrenia, anxiety disorders and autism. OXT has a potential as a marker of autism severity. OXT is an anorexigenic neuropeptide, which is implicated in social cognition and obsessive-compulsive behavior. Plasma oxytocin levels are high in children with Prader-willi syndrome (PWS) compared with unrelated and unaffected siblings. Deficiency of OXT hormone might contribute to pathogenesis of attention deficit/hyperactivity disorder (ADHD).
Stimulates uterine contraction and lactation; increases Na+ excretion; stimulates myometrial GTPase and phospholipase C.

General description

Oxytocin (OXT) is a potent natriuretic hormone encoded by the gene mapped to human chromosome 20p13. It is synthesized along with its carrier protein neurophysin I from its inactive precursor prepro-OXT. OXT gene consists of three exons and two introns where first exon codes for hormone OXT while other exon codes for neurophysin I.

Physical form

Supplied as a powder with a peptide content of ≥ 75%

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

涉药品监管产品
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Certificates of Analysis (COA)

Lot/Batch Number
0000496751
0000496751
0000489773
0000489770
0000489771

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Hydrogen peroxide-induced oxidative damage in peripheral blood lymphocytes from rats chronically treated with corticosterone: The protective effect of oxytocin treatment.
Stanic D
Chemico-Biological Interactions, 256, 134-141 (2016)
Yuetao Chen et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 20(12), 1095-1104 (2013-06-29)
To examine the efficacy of YuanHu painkillers (YHP) as a treatment for primary dysmenorrhea and to reveal YHP's principle formula. A Wistar rat uterine contraction model was utilized in this study. Rats were given 0.698g/kg YHP, 0.07g/kg tetrahydropalmatine (THP; YHP's
Decreased levels of serum oxytocin in pediatric patients with Attention Deficit/Hyperactivity Disorder.
Sasaki T
Psychiatry Research, 228(3), 746-751 (2015)
Elevated plasma oxytocin levels in children with Prader-Willi syndrome compared with healthy unrelated siblings.
Johnson L
American Journal of Medical Genetics. Part A, 170(3), 594-601 (2016)
The human gene for oxytocin-neurophysin I (OXT) is physically mapped to chromosome 20p13 by in situ hybridization.
Rao VV
Cytogenetics and Cell Genetics, 61(4), 271-273 (1992)
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