O1136
Monoclonal Anti-Ornithine Decarboxylase (ODC) antibody produced in mouse
clone ODC-29, ascites fluid
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Synonym(s):
Ornithine Decarboxylase Antibody, Ornithine Decarboxylase Antibody - Monoclonal Anti-Ornithine Decarboxylase (ODC) antibody produced in mouse
Recommended Products
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
ODC-29, monoclonal
mol wt
antigen 53 kDa
contains
15 mM sodium azide
species reactivity
human, mouse
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
immunoprecipitation (IP): suitable
indirect ELISA: suitable
microarray: suitable
western blot: 1:100
isotype
IgG2b
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... ODC1(4953)
mouse ... Odc1(18263)
Related Categories
General description
Monoclonal Anti-Ornithine Decarboxylase (ODC) (mouse IgG2b isotype) is derived from the ODC-29 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from immunized BALB/c mice. Its amino acid sequence is well conserved among species; the overall identity of the amino acid sequences of mouse, rat and human ODC proteins is greater than 90%.
Ornithine decarboxylase (ODC) levels increase rapidly after implantation during mouse embryogenesis. The gene encoding this protein is localized on mouse chromosome 12 and human chromosome 2.
Specificity
By immunohistochemical staining of formalin-fixed, paraffin-embedded human prostate and colon carcinoma, the labeling is confined to epithelial cells.
Immunogen
recombinant mouse ornithine decarboxylase.
Application
Monoclonal Anti-Ornithine Decarboxylase (ODC) antibody produced in mouse has been used in Western blotting.
Monoclonal Anti-Ornithine Decarboxylase (ODC) has also been used in enzyme linked immunosorbent assay (ELISA), immunoprecipitation, immunoblotting and immunohistochemistry.
Biochem/physiol Actions
Ornithine Decarboxylase (ODC) biological activity is rapidly induced to promote cell proliferation in response to hormones, drugs, growth factors, mitogens and tumour promoters. ODC mRNA levels are also elevated in transformed cells including lung carcinomas and human colon adenomas and carcinomas. ODC activity in colorectal carcinomas has been shown to be greater than that in adenomas, which, in turn, is greater than that of normal mucosa. ODC has a half-life of 8-30 min, the shortest half-life time reported in eukaryotic cells.
Ornithine decarboxylase (ODC) converts L-ornithine to putrescine. It has a role in cell replication. ODC is also involved in the polyamine synthesis pathway. The protein is upregulated in cancers. Overexpression of ODC has been associated with carcinogenesis in mice.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
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Find documentation for the products that you have recently purchased in the Document Library.
Ornithine Decarboxylase (ODC) Expression Pattern in Human Prostate Tissues and ODC Transgenic Mice
Lei Young
The Journal of Histochemistry and Cytochemistry, 54(2) (2006)
The methyl-CpG-binding protein MECP2 is required for prostate cancer cell growth
David Bernard
Oncogene, 25, 1358?1366-1358?1366 (2006)
Myc confers androgen-independent prostate cancer cell growth
David Bernard
The Journal of Clinical Investigation, 112(11), 1724?1731-1724?1731 (2003)
Su Xiao et al.
Biotechnology and bioengineering, 113(11), 2403-2415 (2016-05-25)
For the purpose of improving recombinant protein production from mammalian cells, an unbiased, high-throughput whole-genome RNA interference screen was conducted using human embryonic kidney 293 (HEK 293) cells expressing firefly luciferase. A 21,585 human genes were individually silenced with three
Ornithine decarboxylase activity is required for prostatic budding in the developing mouse prostate
Gamat M, et al.
PLoS ONE, 10(10), e0139522-e0139522 (2015)
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