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N9150

Sigma-Aldrich

Nystatin

ready made solution, suitable for cell culture

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Synonym(s):
Nystatin, Fungicidin, Mycostatin
CAS Number:
1400-61-9
MDL number:
MFCD25541651
UNSPSC Code:
12352207
NACRES:
NA.76

product name

Nystatin Ready made solution, suitable for cell culture

biological source

Streptomyces noursei

form

solution

technique(s)

cell culture | mammalian: suitable

shipped in

dry ice

storage temp.

−20°C

SMILES string

O[C@@H]([C@H](C)[C@H](C)O1)[C@@H](C)/C=C/C=C/CC/C=C/C=C/C=C/C=C/[C@H](O[C@@H]2O[C@H](C)[C@@H](O)[C@H](N)[C@@H]2O)C[C@@]3([H])[C@H](C(O)=O)[C@@H](O)C[C@](O)(O3)C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)C[C@@H](O)CC1=O

InChI

1S/C47H75NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-36(53)35(52)20-19-31(49)21-32(50)22-33(51)23-39(55)62-29(3)28(2)42(27)56/h5-6,8,10-18,27-38,40-44,46,49-54,56-58,61H,7,9,19-26,48H2,1-4H3,(H,59,60)/b6-5+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28+,29-,30+,31+,32+,33+,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1

InChI key

VQOXZBDYSJBXMA-QEKUPDCNSA-N

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General description

Nystatin is a fungistatic and fungicidal polyene antibiotic. It binds to ergosterol which increases cell membrane permeability in sensitive fungi. Nystatin is mainly clinically active against Candida species. However, it is also reported to be effective against Aspergillus, Coccidioides immitis, Cryptococcus neoformans, Histoplasma capsulatum, Blastomyces dermatidis, and other yeasts and fungi. Nystatin has also been used to enrich mutants by negative selection in yeasts. The minimum inhibitory concentration (MIC) of Nystatin to Saccharomyces cerevisiae was reported to be 3μg/ml while for clinical isolates of Candida albicans the MIC was reported to be 4-16μg/ml.

Biochem/physiol Actions

Mode of Action: Nystatin acts by binding to ergosterols in fungal cell membranes, increasing permeability of the membrane, and creating nystatin/ergosterol based ion channels. It also functions as a lipid raft-inhibiting reagent and as membrane associated cholesterol.

Antimicrobial spectrum: Nystatin acts against fungi, yeasts and molds.

Features and Benefits

  • Nystatin ready made solution is a fully solubilized formulation of Nystatin with potency of 8000-13000 units/ml according to USP standard.
  • Nystatin ready made solution is 0.2μm filtered, endotoxin.
  • The suggested working concentration of Nystatin ready made solution is 30 units/ml.
  • The ready made solution is light sensitive. It is recommended to store the solution in the dark.
  • It is recommended to avoid freeze thaw cycles of this product. Therefore, it is recommended to aliquot and store at -20°C.

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

农药列管产品

Certificates of Analysis (COA)

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Antifungal drug susceptibility of Candida albicans
Bii CC, Ouko TT, Amukoye E, Githinji LW
East African Medical Journal, 79(3), 143-145 (2002)
Polyene macrolide derivatives. III
Bonner, D. P., Mechlinski, W., and Schaffner, C. P.
The Journal of Antibiotics, 25 (4), 261-262 (1972)
The Biochemical Genetics of Yeast
Fink, G. R.
Enzymologia, 17-A, 59-78 (1970)
Martindale The Extra Pharmacopoeia
Reynolds, J. E. F.
Martindale: The Extra Pharmacopoeia, 432-433 null
Polyene toxicity in renal medulla: injury mediated by transport activity
Brezis, M., et al.
Science, 224, 66-68 (1984)
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