N8912
Monoclonal Anti-NG2 antibody produced in mouse
clone 132.38, purified immunoglobulin, buffered aqueous solution
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Synonym(s):
Anti-Chondroitin Sulfate Proteoglycan Melanoma-associated, Anti-MCSP, Anti-MCSPG, Anti-MEL-CSPG MSK16 Chondroitin Sulfate Proteoglycan NG2
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biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
132.38, monoclonal
form
buffered aqueous solution
species reactivity
rat
technique(s)
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
indirect ELISA: suitable
microarray: suitable
western blot: 1 μg/mL using rat brain neonatal extract
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
rat ... Cspg4(81651)
Related Categories
General description
Chondroitin sulfate proteoglycan 4 (CSPG4) or nerve/glial antigen 2 (NG2) is a growth-inhibitory chondroitin sulfate proteoglycan (CSPG) produced after spinal cord injury. It has a single glycosaminoglycan (GAG) chain. The protein belongs to the transmembrane chondroitin sulfate proteoglycans family.
Immunogen
cell extract of HEK293 cells expressing the D3 domain of rat NG2.
Application
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)
Western Blotting
Immunohistochemistry (1 paper)
Western Blotting
Biochem/physiol Actions
Chondroitin sulfate proteoglycan 4 (CSPG4) or nerve/glial antigen 2 (NG2) stimulates the activation of integrins in dorsal root ganglion neurons. It also has a role in stimulating inflammatory cytokine expression in microglia.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Product No.
Description
Pricing
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Genetically Engineered Artificial Microvesicles Carrying Nerve Growth Factor Restrains the Progression of Autoimmune Encephalomyelitis in an Experimental Mouse Model.
Alatrash, et al.
International Journal of Molecular Sciences, 24 (2023)
Entrapment via Synaptic-Like Connections between NG2 Proteoglycan+ Cells and Dystrophic Axons in the Lesion Plays a Role in Regeneration Failure after Spinal Cord Injury
Angela R
The Journal of Neuroscience (2014)
NG2, a member of chondroitin sulfate proteoglycans family mediates the inflammatory response of activated microglia.
Gao Q, ey .al
Neuroscience and Behavioral Physiology (2010)
Antibody-based proteomics for esophageal cancer: Identification of proteins in the nuclear factor-?B pathway and mitotic checkpoint
Norihisa U
Cancer Science (2009)
Stefano Di Santo et al.
PloS one, 4(5), e5643-e5643 (2009-05-30)
Current evidence suggests that endothelial progenitor cells (EPC) contribute to ischemic tissue repair by both secretion of paracrine factors and incorporation into developing vessels. We tested the hypothesis that cell-free administration of paracrine factors secreted by cultured EPC may achieve
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