N8661
5′-Nucleotidase from Crotalus atrox venom
lyophilized powder, ≥200 units/mg protein
Synonym(s):
5′-Ribonucleotide phosphohydrolase
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About This Item
CAS Number:
Beilstein:
1301486
MDL number:
UNSPSC Code:
12352204
Recommended Products
form
lyophilized powder
specific activity
≥200 units/mg protein
shipped in
dry ice
storage temp.
−20°C
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Unit Definition
One unit will hydrolyze 1.0 μmole of inorganic phosphorus from adenosine 5′-monophosphate per min at pH 9.0 at 37 °C.
Physical form
Lyophilized powder balance primarily trehalose, HEPES and CaCl2
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Paul A Beavis et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(36), 14711-14716 (2013-08-22)
CD73 inhibits antitumor immunity through the activation of adenosine receptors expressed on multiple immune subsets. CD73 also enhances tumor metastasis, although the nature of the immune subsets and adenosine receptor subtypes involved in this process are largely unknown. In this
Helma Pluk et al.
Annals of neurology, 73(3), 397-407 (2013-03-06)
Sporadic inclusion body myositis (sIBM) is an inflammatory myopathy characterized by both degenerative and autoimmune features. In contrast to other inflammatory myopathies, myositis-specific autoantibodies had not been found in sIBM patients until recently. We used human skeletal muscle extracts as
Bertrand Allard et al.
International journal of cancer, 134(6), 1466-1473 (2013-08-29)
CD73 is an ecto-nucleotidase overexpressed in various types of tumors that catabolizes the generation of extracellular adenosine, a potent immunosuppressor. We and others have shown that targeted blockade of CD73 can rescue anti-tumor T cells from the immunosuppressive effects of
Bertrand Allard et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 19(20), 5626-5635 (2013-08-29)
Monoclonal antibodies (mAb) that block programmed death (PD)-1 or cytotoxic T lymphocyte antigen (CTLA-4) receptors have been associated with durable clinical responses against a variety of cancer types and hold great potential as novel cancer therapeutics. Recent evidence suggest that
Smita S Iyer et al.
European journal of immunology, 43(12), 3219-3232 (2013-09-14)
CD4(+) T follicular helper (TFH) cells are central for generation of long-term B-cell immunity. A defining phenotypic attribute of TFH cells is the expression of the chemokine R CXCR5, and TFH cells are typically identified by co-expression of CXCR5 together
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