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Merck
CN

N8661

5′-Nucleotidase from Crotalus atrox venom

lyophilized powder, ≥200 units/mg protein

Synonym(s):

5′-Ribonucleotide phosphohydrolase

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About This Item

CAS Number:
UNSPSC Code:
12352204
Beilstein/REAXYS Number:
1301486
MDL number:
EC Number:
Specific activity:
≥200 units/mg protein
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form

lyophilized powder

specific activity

≥200 units/mg protein

shipped in

dry ice

storage temp.

−20°C

Physical form

Lyophilized powder balance primarily trehalose, HEPES and CaCl2

Other Notes

One unit will hydrolyze 1.0 μmole of inorganic phosphorus from adenosine 5′-monophosphate per min at pH 9.0 at 37 °C.

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Francis Coffey et al.
The Journal of experimental medicine, 211(2), 329-343 (2014-02-05)
Numerous studies indicate that γδ T cell receptor (γδTCR) expression alone does not reliably mark commitment of early thymic progenitors to the γδ fate. This raises the possibility that the γδTCR is unable to intrinsically specify fate and instead requires
Smita S Iyer et al.
European journal of immunology, 43(12), 3219-3232 (2013-09-14)
CD4(+) T follicular helper (TFH) cells are central for generation of long-term B-cell immunity. A defining phenotypic attribute of TFH cells is the expression of the chemokine R CXCR5, and TFH cells are typically identified by co-expression of CXCR5 together
Bertrand Allard et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 19(20), 5626-5635 (2013-08-29)
Monoclonal antibodies (mAb) that block programmed death (PD)-1 or cytotoxic T lymphocyte antigen (CTLA-4) receptors have been associated with durable clinical responses against a variety of cancer types and hold great potential as novel cancer therapeutics. Recent evidence suggest that
Paul A Beavis et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(36), 14711-14716 (2013-08-22)
CD73 inhibits antitumor immunity through the activation of adenosine receptors expressed on multiple immune subsets. CD73 also enhances tumor metastasis, although the nature of the immune subsets and adenosine receptor subtypes involved in this process are largely unknown. In this
Helma Pluk et al.
Annals of neurology, 73(3), 397-407 (2013-03-06)
Sporadic inclusion body myositis (sIBM) is an inflammatory myopathy characterized by both degenerative and autoimmune features. In contrast to other inflammatory myopathies, myositis-specific autoantibodies had not been found in sIBM patients until recently. We used human skeletal muscle extracts as

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