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Merck
CN

N7787

NS3694

≥98%, powder

Synonym(s):

4-Chloro-2-[3-(3-trifluoromethyl-phenyl)-ureido]benzoic acid

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About This Item

Empirical Formula (Hill Notation):
C15H10ClF3N2O3
CAS Number:
426834-38-0
Molecular Weight:
358.70
NACRES:
NA.77
PubChem Substance ID:
24724557
UNSPSC Code:
12352200
MDL number:
MFCD00249000

Key Documents

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Product Name

NS3694, ≥98%, powder

InChI

1S/C15H10ClF3N2O3/c16-9-4-5-11(13(22)23)12(7-9)21-14(24)20-10-3-1-2-8(6-10)15(17,18)19/h1-7H,(H,22,23)(H2,20,21,24)

SMILES string

OC(=O)c1ccc(Cl)cc1NC(=O)Nc2cccc(c2)C(F)(F)F

InChI key

GNCZTZCPXFDPLI-UHFFFAOYSA-N

assay

≥98%

form

powder

solubility

DMSO: soluble 22 mg/mL
H2O: insoluble <5 mg/mL

storage temp.

2-8°C

Quality Level

200

Gene Information

human ... GRIK1(2897)

Related Categories

Application

NS3694 may be used as an apoptosis inhibitor to study the relationship between the cellular mechanisms controlled by amputation-induced myeloid lineage activity.

Biochem/physiol Actions

NS3694 can prevent the active apoptosome complex formation.
NS3694 is an Inhibitor of apoptosome formation.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000119947
0000119948
0000099999
0000031542
BGBC2089

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Cindy X Kha et al.
Experimental eye research, 169, 38-47 (2018-01-23)
Vertebrate eye development is complex and requires early interactions between neuroectoderm and surface ectoderm during embryogenesis. In the African clawed frog, Xenopus laevis, individual eye tissues such as the retina and lens can undergo regeneration. However, it has been reported
Jovany J Franco et al.
Molecular biology of the cell, 30(16), 1890-1899 (2019-02-21)
Epithelial wound healing requires a complex orchestration of cellular rearrangements and movements to restore tissue architecture and function after injury. While it is well known that mechanical forces can affect tissue morphogenesis and patterning, how the biophysical cues generated after
Developmental dependence for functional eye regrowth in Xenopus laevis.
Cindy X Kha et al.
Neural regeneration research, 13(10), 1735-1737 (2018-08-24)
Ulrik Lademann et al.
Molecular and cellular biology, 23(21), 7829-7837 (2003-10-16)
The release of mitochondrial proapoptotic proteins into the cytosol is the key event in apoptosis signaling, leading to the activation of caspases. Once in the cytosol, cytochrome c triggers the formation of a caspase-activating protein complex called the apoptosome, whereas
Can Aztekin et al.
Development (Cambridge, England), 147(3) (2020-01-29)
Regeneration-competent vertebrates are considered to suppress inflammation faster than non-regenerating ones. Hence, understanding the cellular mechanisms affected by immune cells and inflammation can help develop strategies to promote tissue repair and regeneration. Here, we took advantage of naturally occurring tail
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