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N6664

Sigma-Aldrich

Neurodazine

≥98% (HPLC)

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Synonym(s):
2-[5-(3-Chlorophenyl)-2-furanyl]-4,5-bis(4-methoxyphenyl)-1H imidazole
Empirical Formula (Hill Notation):
C27H21ClN2O3
CAS Number:
937807-66-4
Molecular Weight:
456.92
MDL number:
MFCD08906055
UNSPSC Code:
12352203
PubChem Substance ID:
329818668
NACRES:
NA.25

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

yellow

solubility

DMSO: >20 mg/mL

storage temp.

−20°C

SMILES string

COc1ccc(cc1)-c2nc([nH]c2-c3ccc(OC)cc3)-c4ccc(o4)-c5cccc(Cl)c5

InChI

1S/C27H21ClN2O3/c1-31-21-10-6-17(7-11-21)25-26(18-8-12-22(32-2)13-9-18)30-27(29-25)24-15-14-23(33-24)19-4-3-5-20(28)16-19/h3-16H,1-2H3,(H,29,30)

InChI key

FEEOFPAEDSMOTO-UHFFFAOYSA-N

Biochem/physiol Actions

Neurodazine is a promoter of neurogenesis. It induces a generation of new nerve cells from skeletal muscle fibers both immature, differentiated myotubes and mature skeletal muscle. Neurodazine promotes the expression of neuron-specific markers in treated C2C12 cells (neurogenesis). In addition, in conjunction with a microtubule-destabilizing agent, Neurodazine allows neurogenic conversion of both differentiated immature myotubes and mature skeletal muscle. Neurodazine is a potential alternative approach to using stem cells.

Pictograms

Skull and crossbonesCorrosion
GHS06,GHS05

Signal Word

Danger

Hazard Statements

H301,H318,H413

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Chronic 4 - Eye Dam. 1

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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