N6413
Anti-NR4A2 (N-terminal) antibody produced in rabbit
~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution
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Synonym(s):
Anti-HZF-3, Anti-NOT, Anti-NURR1, Anti-RNR1, Anti-TINUR
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
~70 kDa
species reactivity
human, mouse, rat
concentration
~1.5 mg/mL
technique(s)
indirect immunofluorescence: 4-8 μg/mL using 3T3 cells
western blot: 1-2 μg/mL using HEK-293T cell lysate expressing human NR4A2
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... NR4A2(4929)
mouse ... Nr4a2(18227)
rat ... Nr4a2(54278)
General description
Nuclear receptor subfamily 4 group A member 2 (NR4A2) is part of transcriptional regulator subfamily, under the family of nuclear hormone receptors. It is a transcription factor expressed in the brain and T-cells.
Application
Anti-NR4A2 (N-terminal) antibody has been used in
- immunoblotting
- immunofluorescence
- western blotting
Biochem/physiol Actions
NR4A2 binds the NGFI-B (nerve growth factor-induced clone B) response element (NBRE) sequence (AAAGGTCA) as monomer. NR4A2 is induced by multiple extracellular signals, including fatty acids, stress, growth factors and neurotransmitters in a cell type specific manner. Hepatic expression of NR4A2 is induced by cAMP in response to glucagon and fasting. NR4A2 is essential for the differentiation of nigral dopaminergic neurons. NR4A2 mutations have been associated with disorders related to dopaminergic dysfunction, including Parkinson′s disease, schizophrenia.
Nuclear receptor subfamily 4 group A member 2 (NR4A2) acts as an activator of tyrosine hydroxylase. It is crucial for the process of DNA repair by melanocortin-1 receptor.
Target description
NR4A2 (N-terminal) encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, includ
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
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Huimin Gao et al.
Scientific reports, 6, 34403-34403 (2016-09-30)
The nuclear orphan receptor, Nur77 plays important roles in neuroimflammation, apoptosis, and dopaminergic neurodegeneration. We conducted a further mechanistic investigation into the association of Nur77 with cell death. Cytosporone B (Csn-B), an agonist for Nur77, and Nur77 knockdown were adopted
Ahmed M Ali et al.
Chemistry & biology, 22(11), 1531-1539 (2015-11-23)
Current approaches for optogenetic control of transcription do not mimic the activity of endogenous transcription factors, which act at numerous sites in the genome in a complex interplay with other factors. Optogenetic control of dominant negative versions of endogenous transcription
Enhancing beta-catenin activity via GSK3beta inhibition protects PC12 cells against rotenone toxicity through Nurr1 induction
Zhang L, et al.
PLoS ONE, 11(4), e0152931-e0152931 (2016)
Mutations in NR4A2 associated with familial Parkinson disease
Le W D, et al.
Nature Genetics, 33(1), 85-85 (2002)
Hiroko Ishii et al.
American journal of cancer research, 11(2), 441-457 (2021-02-13)
Cancer stem cell (CSC) is considered as a cause of cancer recurrence and metastasis. Simultaneously CSCs are responsible for the heterogeneous population in tumor tissues due to their differentiation potential. However, the characterizations of CSCs are still not enough and
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