N5538
Monoclonal Anti-3-Nitrotyrosine antibody produced in mouse
clone 18G4, purified immunoglobulin, buffered aqueous glycerol solution
Sign Into View Organizational & Contract Pricing
All Photos(1)
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
18G4, monoclonal
form
buffered aqueous glycerol solution
mol wt
antigen ~55 kDa
species reactivity
wide range
technique(s)
western blot: 1:1,000 using mouse and rat brain
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
nitration (Tyr)
Gene Information
human ... NOS1(4842)
Looking for similar products? Visit Product Comparison Guide
General description
3-nitrotyrosine (3-NT) is synthesized by the incorporation of nitro triatomic group (-NO2) at the third position of the phenolic ring in the tyrosine residue, in response to the production of peroxynitrite in the oxidative and nitrosative stress.
Immunogen
3-Nitrotyrosine-KLH.
Application
Monoclonal Anti-3-Nitrotyrosine antibody produced in mouse has been used in western blot analysis and immunohistochemistry.
Biochem/physiol Actions
3-Nitrotyrosine (3-NT) in tissue extracts is a marker for the determination of protein damage induced by peroxynitrite. 3-NT is used as a biomarker to determine the protein nitration, associated with various disorders. It is implicated in diseases characterized by endothelial dysfunction as in stroke, myocardial infarction, atherosclerosis and diabetes.
Target description
Monoclonal Anti-3-Nitrotyrosine recognizes 3-nitrotyrosine in most species. Protein tyrosine nitration results in a post-translational modification that is increasingly receiving attention as an important component of nitric oxide signaling.
Physical form
Solution in 20 mM sodium phosphate, 150 mM sodium chloride, 50% glycerol, and 3 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Pengcheng Xu et al.
Frontiers in cellular neuroscience, 15, 804345-804345 (2022-01-04)
Mutations in a number of genes encoding mitochondrial aminoacyl-tRNA synthetases lead to non-syndromic and/or syndromic sensorineural hearing loss in humans, while their cellular and physiological pathology in cochlea has rarely been investigated in vivo. In this study, we showed that
Phytochemical analysis and biological properties of Cyperus rotundus L.
Kumar KH, et al.
Industrial Crops and Products, 52, 815-826 (2014)
Cardiotrophin-1 reduces ischemia/reperfusion injury during liver transplant
Aguilar-Melero P, et al.
The Journal of Surgical Research, 181(2), e83-e91 (2013)
Amanda M Eccardt et al.
Catalysts (Basel, Switzerland), 12(8) (2023-05-01)
Iron porphyrin molecules such as hemin and iron(III) 4,4',4″,4‴-(porphine-5,10,15,20-tetrayl)tetrakis(benzoic acid) (FeTBAP) have previously been shown to influence insulin signaling and glucose metabolism. We undertook this study to determine whether a catalytic action of iron porphyrin compounds would be related to
Andrographolide Ameliorates Diabetic Cardiomyopathy in Mice by Blockage of Oxidative Damage and NF-kappaB-Mediated Inflammation
Liang E, et al.
Oxidative Medicine and Cellular Longevity, 2018 (2018)
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service