All Photos(1)

Documents

N5536

Nefazodone hydrochloride

Name: Nefazodone hydrochloride
Brand: SIGMA

≥98% (HPLC), solid, antidepressant

Synonym(s):

2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ethyl- 2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one hydrochloride, BMY-13754, MJ-13754-1, Serzone

Sign Into View Organizational & Contract Pricing

All Photos(1)

About This Item

Empirical Formula (Hill Notation):

C₂₅H₃₂ClN₅O₂ · HCl

CAS Number:

82752-99-6

Molecular Weight:

506.47

MDL number:

MFCD00935760

UNSPSC Code:

12352200

PubChem Substance ID:

24724551

NACRES:

NA.77

product name

Nefazodone hydrochloride, ≥98% (HPLC), solid

Quality Level

100

Assay

≥98% (HPLC)

form

solid

storage condition

desiccated

color

white

solubility

DMSO: ≥10 mg/mL
H₂O: insoluble

originator

Bristol-Myers Squibb

SMILES string

O=C1N(CCCN2CCN(C3=CC=CC(Cl)=C3)CC2)N=C(CC)N1CCOC4=CC=CC=C4.Cl

InChI

1S/C25H32ClN5O2.ClH/c1-2-24-27-31(25(32)30(24)18-19-33-23-10-4-3-5-11-23)13-7-12-28-14-16-29(17-15-28)22-9-6-8-21(26)20-22;/h3-6,8-11,20H,2,7,12-19H2,1H3;1H

InChI key

DYCKFEBIOUQECE-UHFFFAOYSA-N

Gene Information

human ... HTR2A(3356) , HTR2C(3358) , SLC6A2(6530) , SLC6A4(6532)

Looking for similar products? Visit Product Comparison Guide

Biochem/physiol Actions

Novel antidepressant; mixed 5-HT_2A serotonin receptor antagonist/serotonin uptake inhibitor.

Features and Benefits

This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

In vitro assessment of mitochondrial dysfunction and cytotoxicity of nefazodone, trazodone, and buspirone.

James A Dykens et al.

Toxicological sciences : an official journal of the Society of Toxicology, 103(2), 335-345 (2008-03-18)

Mitochondrial toxicity is increasingly implicated in a host of drug-induced organ toxicities, including hepatotoxicity. Nefazodone was withdrawn from the U.S. market in 2004 due to hepatotoxicity. Accordingly, we evaluated nefazodone, another triazolopyridine trazodone, plus the azaspirodecanedione buspirone, for cytotoxicity and

Differential effects of treatments for chronic depression: a latent growth model reanalysis.

Niklaus Stulz et al.

Journal of consulting and clinical psychology, 78(3), 409-419 (2010-06-03)

Psychotherapy-pharmacotherapy combinations are frequently recommended for the treatment of chronic depressive disorders. Our aim in this novel reanalysis of archival data was to identify patient subgroups on the basis of symptom trajectories and examine the clinical significance of the resultant

Clinical and genetic correlates of suicidal ideation during antidepressant treatment in a depressed outpatient sample.

Nader Perroud et al.

Pharmacogenomics, 12(3), 365-377 (2011-04-01)

This study investigated clinical and genetic predictors of increasing suicidal ideation during antidepressant treatment. A total of 131 depressed outpatients were allocated to four antidepressants (paroxetine, venlafaxine, clomipramine or nefazodone) in a sequential step procedure until remission. Suicidality was assessed

Nefazodone. A review of its pharmacology and clinical efficacy in the management of major depression.

R Davis et al.

Drugs, 53(4), 608-636 (1997-04-01)

Nefazodone hydrochloride is a phenylpiperazine antidepressant with a mechanism of action that is distinct from those of other currently available drugs. It potently and selectively blocks postsynaptic serotonin (5-hydroxytryptamine; 5-HT) 5-HT2A receptors and moderately inhibits serotonin and noradrenaline (norepinephrine) reuptake.

Long-term exposure of mouse pancreatic islets to oleate or palmitate results in reduced glucose-induced somatostatin and oversecretion of glucagon.

S C Collins et al.

Diabetologia, 51(9), 1689-1693 (2008-07-16)

Long-term exposure to NEFAs leads to inhibition of glucose-induced insulin secretion. We tested whether the release of somatostatin and glucagon, the two other major islet hormones, is also affected. Mouse pancreatic islets were cultured for 72 h at 4.5 or

View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service