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Merck
CN

N5504

Naphazoline hydrochloride

Synonym(s):

2-(1-Naphthylmethyl)imidazoline hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C14H14N2 · HCl
CAS Number:
550-99-2
Molecular Weight:
246.74
NACRES:
NA.77
PubChem Substance ID:
24278592
UNSPSC Code:
12352200
EC Number:
208-989-2
MDL number:
MFCD00012554

Key Documents

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InChI key

DJDFFEBSKJCGHC-UHFFFAOYSA-N

InChI

1S/C14H14N2.ClH/c1-2-7-13-11(4-1)5-3-6-12(13)10-14-15-8-9-16-14;/h1-7H,8-10H2,(H,15,16);1H

SMILES string

Cl.C1CN=C(Cc2cccc3ccccc23)N1

form

powder

originator

Allergan

Quality Level

100

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)

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Biochem/physiol Actions

α-adrenoceptor agonist; imidazoline receptor agonist; vasoconstrictor.
Naphazoline hydrochloride is a sympathomimetic agent. It is also considered as a conjunctival decongestant.

Features and Benefits

This compound was developed by Allergan. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
BCCM0849
BCCM0848
BCCH9982
BCCG7846
BCCD1190

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M Gelardi et al.
Journal of biological regulators and homeostatic agents, 23(2), 79-84 (2009-07-11)
A wide variety of nasal irrigation systems are currently available for improving nasal symptoms, but few studies have compared their effectiveness with respect to patient age and type of nasal disease. This pilot study aims to compare the efficacy of
Marie Granier et al.
Canadian journal of anaesthesia = Journal canadien d'anesthesie, 56(2), 102-108 (2009-02-28)
Septorhinoplasty is a traumatic procedure that is associated with epistaxis and postoperative pain. The primary objective of this randomized double-blind controlled trial was to determine whether intranasal 5% lidocaine plus naphazoline decreases postoperative pain and lessens the use of rescue
Nan-Nan Wang et al.
Luminescence : the journal of biological and chemical luminescence, 24(3), 178-182 (2009-03-03)
A sensitive and simple flow-injection chemiluminescence (FI-CL) method, which was based on the CL intensity generated from the redoxreaction of potassium permanganate (KMnO4)-formaldehyde in vitriol (H2SO4) medium, has been developed, validated and applied for the determination of naphazoline hydrochloride and
Yuriko Nagane et al.
Muscle & nerve, 44(1), 41-44 (2011-04-15)
When treating ocular myasthenia gravis (MG), the risk/benefit profile of corticosteroids is unclear, and acetylcholinesterase inhibitors are not very effective. We examined the efficacy of topical naphazoline in the treatment of myasthenic blepharoptosis. Sixty MG patients with blepharoptosis (32 with
Eman Y Z Frag et al.
The Analyst, 136(2), 332-339 (2010-10-21)
This paper describes the development of screen-printed (SPE) and carbon paste (CPE) sensors for the rapid and sensitive quantification of naphazoline hydrochloride (NPZ) in pharmaceutical formulations. This work compares the electroactivity of conventional carbon paste and screen-printed carbon paste electrodes
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