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N5163

Sigma-Aldrich

Anti-NOTCH4 antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

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Synonym(s):
Anti-INT3, Anti-Notch homolog 4 (Drosophila)
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~230 kDa
antigen ~80 kDa

species reactivity

mouse, human, rat

concentration

~1 mg/mL

technique(s)

immunohistochemistry: 1:100-1:200
western blot: 1:500-1:1,000

UniProt accession no.

Q99466

application(s)

research pathology

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... NOTCH4(4855)
mouse ... Notch4(18132)
rat ... Notch4(406162)

General description

NOTCH homolog-4 (NOTCH4) is expressed in breast cancer.

Immunogen

synthetic peptide corresponding to residues 1506-1524 of human NOTCH4. This sequence is 89% identical in mouse and rat.

Biochem/physiol Actions

NOTCH homolog-4 (NOTCH4) has an intracellular domain which detaches from the protein on activation. This domain then translocates to the nucleus and modulates transcription of genes. NOTCH4 also activates various pathways and contributes to carcinogenesis. Mutations in the gene encoding the protein may be linked to schizophrenia.

Physical form

solution in phosphate buffered saline, containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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NOTCH4 is a potential therapeutic target for triple-negative breast cancer.
Nagamatsu I
Anticancer Research, 34(1), 69-80 (2014)
Genetic variability testing of neurodevelopmental genes in schizophrenic patients.
Terzic T
Journal of Molecular Neuroscience, 56(1), 205-211 (2015)
AKT and 14-3-3 regulate Notch4 nuclear localization.
Ramakrishnan G
Scientific Reports, 5, 8782-8782 (2015)
Cuijuan Qian et al.
Molecular and cellular biochemistry, 401(1-2), 165-174 (2014-12-17)
Gastric cancer (GC) is one of the most common cancers and lethal malignancies in the world. Discovering novel biomarkers that correlate with GC may provide opportunities to reduce the severity of GC. As one of Notch receptor family members in
Fernanda Silva et al.
Oncology letters, 12(4), 2686-2691 (2016-10-05)
Epithelial ovarian cancer is the most lethal gynecologic malignancy, despite advances in treatment. The most common histological type, high-grade ovarian serous carcinoma (OSC) is usually diagnosed at an advanced stage, and although these types of tumors frequently respond to surgery
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