N4912
NMA-Gly-Cys-Gly-Val-Leu-Leu-Lys(dnp)-Arg-Arg-NH2 trifluoroacetate salt
≥95% (HPLC), solid
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Synonym(s):
NMA-GCGVLLK(dnp)RR-NH2
Empirical Formula (Hill Notation):
C56H90N20O14S · xC2HF3O2
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Quality Level
Assay
≥95% (HPLC)
form
solid
storage condition
desiccated
protect from light
under inert gas
color
yellow
solubility
H2O: ≥0.5 mg/mL
shipped in
wet ice
storage temp.
−20°C
Amino Acid Sequence
Nme-Asp-Gly-Cys-Gly-Val-Leu-Leu-Lys-DNP-Arg-Arg-NH2
Biochem/physiol Actions
Notch 1 Peptide, fluorogenic
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Certificates of Analysis (COA)
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Yoshihito Taniguchi et al.
Proceedings of the National Academy of Sciences of the United States of America, 99(6), 4014-4019 (2002-03-14)
Notch receptors undergo three distinct proteolytic cleavages during maturation and activation. The third cleavage occurs within the plasma membrane and results in the release and translocation of the intracellular domain into the nucleus to execute Notch signaling. This so-called gamma-secretase
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