N4413
Anti-Nanog antibody produced in rabbit
~1 mg/mL, affinity isolated antibody, buffered aqueous solution
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Synonym(s):
Anti-FLJ12581, Anti-Nanog homeobox
UNSPSC Code:
12352203
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
concentration
~1 mg/mL
technique(s)
western blot: 1:1,000-1:2,000
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... NANOG(79923)
mouse ... Nanog(71950)
rat ... Nanog(414065)
General description
Nanog homeobox (NANOG) is a 305 amino acid transcription factor. It is expressed in many types of cancers.
Immunogen
synthetic peptide corresponding to an internal sequence of human Nanog.
Biochem/physiol Actions
Nanog homeobox (NANOG) works with pluripotency factors like sex determining region Y-box 2 (SOX2). It is involved in conserving the pluripotency and self-renewal properties of embryonic stem cells. NANOG also associates with the c-Jun promoter.
Physical form
solution in phosphate buffered saline, containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Certificates of Analysis (COA)
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NANOG upregulates c-Jun oncogene expression through binding the c-Jun promoter.
Lin Y
Molecular Carcinogenesis, 54(11), 1407-1416 (2015)
Shuai Gong et al.
Molecular carcinogenesis, 54(9), 679-687 (2015-05-28)
As one of the key pluripotency transcription factors, NANOG plays a critical role in maintaining the self-renewal and pluripotency in normal embryonic stem cells. Recent data indicate that NANOG is expressed in a variety of cancers and its expression correlates
Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells.
Hayashi Y
Proceedings of the National Academy of Sciences of the USA, 112(15), 4666-4671 (2015)
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