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N3414

Sigma-Aldrich

NSC348884 hydrate

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Synonym(s):
N1,N2-bis((3-imino-6-methyl-3H-indol-2-yl)methyl)-N1,N2-bis((6-methyl-1H-benzo[d]imidazol-2-yl)methyl)ethane-1,2-diamine hydrate
Empirical Formula (Hill Notation):
C38H40N10 · xH2O
CAS Number:
1173022-34-8
Molecular Weight:
636.79 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
329818608
NACRES:
NA.77

form

solid

Quality Level

100

color

white

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

O.Cc1ccc2[nH]c(CN(CCN(Cc3nc4cc(C)ccc4[nH]3)Cc5nc6cc(C)ccc6[nH]5)Cc7nc8cc(C)ccc8[nH]7)nc2c1

InChI

1S/C38H40N10.H2O/c1-23-5-9-27-31(15-23)43-35(39-27)19-47(20-36-40-28-10-6-24(2)16-32(28)44-36)13-14-48(21-37-41-29-11-7-25(3)17-33(29)45-37)22-38-42-30-12-8-26(4)18-34(30)46-38;/h5-12,15-18H,13-14,19-22H2,1-4H3,(H,39,43)(H,40,44)(H,41,45)(H,42,46);1H2

InChI key

AFSOHVUGOYTFCG-UHFFFAOYSA-N

Biochem/physiol Actions

NSC 348884 is a putative inhibitor of nucleophosmin (NPM). NSC 348884 inhibits NMP oligomer formation, up-regulates p53 and induces apoptosis.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Rachy Abraham et al.
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Chikungunya virus (CHIKV), a positive-stranded RNA virus, can cause neurological complications by infecting the major parenchymal cells of the brain such as neurons and astrocytes. A proteomic analysis of CHIKV-infected human astrocytic cell line U-87 MG revealed tight functional associations

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