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N3014

Sigma-Aldrich

β-Nicotinamide adenine dinucleotide hydrate

suitable for cell culture, ≥96.5% (HPLC), ≥96.5% (spectrophotometric assay), from yeast

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Synonym(s):
β-DPN, β-NAD, Coenzyme 1, Cozymase, DPN, Diphosphopyridine nucleotide, NAD, Nadide
Empirical Formula (Hill Notation):
C21H27N7O14P2 · xH2O
CAS Number:
53-84-9
Molecular Weight:
663.43 (anhydrous basis)
MDL number:
MFCD00036253
UNSPSC Code:
41106305
eCl@ss:
39200202
PubChem Substance ID:
24897613
NACRES:
NA.55

biological source

yeast

Quality Level

200

Assay

≥96.5% (HPLC)
≥96.5% (spectrophotometric assay)

form

powder

mol wt

Mw 663.43 g/mol

technique(s)

cell culture | mammalian: suitable

impurities

≤3% Acetone

color

white to off-white

solubility

H2O: 50 mg/mL

storage temp.

−20°C

SMILES string

NC1=NC=NC2=C1N=CN2.O[C@@H]3[C@@H](COP(O)(OP(OC[C@@H](O4)[C@@H](O)[C@@H](O)[C@H]4[N+]5=CC=CC(C(N)=O)=C5)([O-])=O)=O)OC[C@@H]3O

InChI

1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1

InChI key

BAWFJGJZGIEFAR-NNYOXOHSSA-N

Gene Information

human ... ESR1(2099) , ESR2(2100)

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Application


  • Spectroelectrochemical Enzyme Sensor System for Acetaldehyde Detection in Wine.: This study explores the development of a novel sensor system using β-Nicotinamide adenine dinucleotide hydrate to detect acetaldehyde in wine, enhancing the accuracy of wine quality control (Ibáñez et al., 2022).

  • Screening of Lactate Dehydrogenase Inhibitor from Bioactive Compounds in Natural Products by Electrophoretically Mediated Microanalysis.: The research utilizes β-Nicotinamide adenine dinucleotide hydrate to screen potential lactate dehydrogenase inhibitors, which could lead to new therapeutic agents for diseases such as cancer (Li et al., 2021).

  • Combination of NAD(+) and NADPH Offers Greater Neuroprotection in Ischemic Stroke Models by Relieving Metabolic Stress.: This research highlights the neuroprotective effects of NAD+ and NADPH in stroke models, emphasizing the potential therapeutic applications of β-Nicotinamide adenine dinucleotide hydrate in neuroprotection (Huang et al., 2018).

Biochem/physiol Actions

Electron acceptor

Packaging

Packaged by solid weight.

Other Notes

Meets or exceeds NRC specifications.
This is the common form of NAD.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Ana P Gomes et al.
Cell, 155(7), 1624-1638 (2013-12-24)
Ever since eukaryotes subsumed the bacterial ancestor of mitochondria, the nuclear and mitochondrial genomes have had to closely coordinate their activities, as each encode different subunits of the oxidative phosphorylation (OXPHOS) system. Mitochondrial dysfunction is a hallmark of aging, but
Jeerus Sucharitakul et al.
The Journal of biological chemistry, 288(49), 35210-35221 (2013-10-17)
3-Hydroxybenzoate 6-hydroxylase (3HB6H) from Rhodococcus jostii RHA1 is an NADH-specific flavoprotein monooxygenase that catalyzes the para-hydroxylation of 3-hydroxybenzoate (3HB) to form 2,5-dihydroxybenzoate (2,5-DHB). Based on results from stopped-flow spectrophotometry, the reduced enzyme-3HB complex reacts with oxygen to form a C4a-peroxy
Christian Dölle et al.
The FEBS journal, 280(15), 3530-3541 (2013-04-27)
Mitochondrial metabolism is intimately connected to the universal coenzyme NAD. In addition to its role in redox reactions of energy transduction, NAD serves as substrate in regulatory reactions that lead to its degradation. Importantly, all types of the known NAD-consuming
Brian J North et al.
The EMBO journal, 33(13), 1438-1453 (2014-05-16)
Mice overexpressing the mitotic checkpoint kinase gene BubR1 live longer, whereas mice hypomorphic for BubR1 (BubR1(H/H)) live shorter and show signs of accelerated aging. As wild-type mice age, BubR1 levels decline in many tissues, a process that is proposed to
Anna Ferretta et al.
Biochimica et biophysica acta, 1842(7), 902-915 (2014-03-04)
Mitochondrial dysfunction and oxidative stress occur in Parkinson's disease (PD), but the molecular mechanisms controlling these events are not completely understood. Peroxisome proliferator-activated receptor-gamma coactivator-1α (PGC-1α) is a transcriptional coactivator known as master regulator of mitochondrial functions and oxidative metabolism.
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